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Gum disease could throw off your Body's daily rhythm, study finds

NCT ID NCT07452783

Knowledge-focused Sponsor: Inonu University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at whether gum inflammation affects the genes that control the body's daily (circadian) clock. Researchers collected gum tissue from 60 healthy adults with similar sleep habits, comparing those with healthy gums, gingivitis, or advanced gum disease. They measured the activity of clock-related genes and inflammatory markers, aiming to see if gum disease itself disrupts local circadian rhythms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help explain why gum disease worsens at certain times of day and point to new ways to treat it by targeting the body's internal clock.
What could go wrong
This is a small, observational study that only looks at gene activity in tissue samples. It does not test any treatment, so any potential applications are far off and uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Jan 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Systemically healthy adult individuals seeking care at the Department of Periodontology, Inonu University Faculty of Dentistry, were recruited. Participants were categorized into three groups based on periodontal status: periodontally healthy, gingivitis, and Stage III Grade B periodontitis according to the 2018 classification of periodontal diseases. All participants required clinically indicated periodontal procedures from which gingival tissue samples could be obtained.

Ages

25 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older * Systemically healthy individuals * Presence of at least 20 natural teeth * Individuals classified as periodontally healthy, gingivitis, or Stage III Grade B periodontitis according to the 2018 classification of periodontal diseases * Willingness to provide written informed consent Exclusion Criteria: * Presence of any systemic disease affecting periodontal status (e.g., diabetes mellitus, autoimmune diseases, cardiovascular diseases) * Use of antibiotics or anti-inflammatory medications within the previous 3 months * Periodontal therapy within the last 6 months * Current smokers or individuals who quit smoking within the past 5 years * Pregnancy or lactation * Use of medications known to influence immune or inflammatory responses * History of systemic conditions that may affect wound healing

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Conditions

The condition(s) this trial relates to.

gingivitis Inflammation periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis Periodontitis

Contacts and locations

Locations

  • Inonu University Faculty of Dentistry

    Malatya, 44210, Turkey (Türkiye)

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Other studies related to the condition(s) this trial covers.