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Patch over pill? new study tests pain relief after root canal

NCT ID NCT07610265

Symptom relief Sponsor: Nims University Rajasthan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether pain-relieving skin patches work as well as oral tablets for pain after root canal treatment. 80 adults with tooth pain received either a ketoprofen or fentanyl patch, or an oral medication. They rated their pain over 48 hours. The goal was to see if patches could be a good alternative to pills.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketoprofen transdermal patch and fentanyl transdermal patch
What this could lead to
If successful, this could show that skin patches offer a convenient alternative to oral painkillers after root canal treatment.
What could go wrong
This is a small, completed Phase 4 trial with only 80 participants. Results may not apply to everyone, and skin patches can cause local irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

80 people

The number who actually took part.

Started

Apr 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 to 60 years * Patients diagnosed with symptomatic irreversible pulpitis or symptomatic apical periodontitis * Multi-rooted teeth indicated for single-visit root canal treatment * Patients experiencing moderate to severe preoperative pain * Systemically healthy individuals * Patients willing to participate and comply with follow up protocol Exclusion Criteria: * Patients with a known history of hypersensitivity or adverse reactions to diclofenac, ketoprofen, or other non-steroidal anti-inflammatory drugs (NSAIDs), including reactions such as bronchospasm, shock, or urticaria, were excluded from the study. * Individuals with a history of active gastric or duodenal ulceration within the previous six months were not included. * Patients who were currently receiving NSAIDs or corticosteroid therapy during the study period were excluded. * Participants with a medical history of systemic conditions such as bronchial asthma, epilepsy, inflammatory bowel disease, severe hepatic or renal impairment, dengue fever, or any psychological or psychiatric disorders were not considered eligible for inclusion. * Pregnant and lactating women were excluded from the study. * Patients with a history of antibiotic use during the study period were also excluded.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post endodontic pain

Contacts and locations

Locations

  • Department of Conservative Dentistry and Endodontics, Nims Dental College and Hospital, Nims University, Rajasthan

    Jaipur, Rajasthan, 303121, India

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