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Common painkillers may skew tooth nerve tests, study finds

NCT ID NCT07618494

Knowledge-focused Sponsor: Pakistan Institute of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking common painkillers like paracetamol or ibuprofen before a dental pulp sensitivity test changes the results. 184 healthy adults received either a painkiller or a placebo, and their tooth nerve responses were measured. The goal is to help dentists avoid false readings that could lead to wrong treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Paracetamol and Ibuprofen
What this could lead to
If successful, this study could help dentists get more accurate pulp test results, reducing unnecessary root canals or missed diagnoses.
What could go wrong
This is a small, completed trial with healthy volunteers, not patients with tooth pain. Results may not apply to real-world dental visits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

184 people

The number who actually took part.

Started

Feb 2026

Finished

May 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 6.Sample selection: Inclusion criteria: Healthy adults aged 18-40 years with intact, caries-free maxillary central incisors. Teeth showing normal baseline response to sensibility testing. No use of any analgesic, sedative, or psychotropic medication within the last 24 hours. Participants willing to comply with study procedures and follow-up schedule. Exclusion Criteria: Teeth with restorations, fractures, attrition, or periapical pathology. Patients with systemic diseases influencing pain perception (e.g., diabetes, neuropathy). History of hypersensitivity or contraindication to the tested analgesics. Pregnant or lactating women. Participants with a history of long-term analgesic or corticosteroid use. Exclusion Criteria: \-

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Conditions

The condition(s) this trial relates to.

dental pulp disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpal condition

Contacts and locations

Locations

  • Ayesha Noor

    Islamabad, Federal, 44000, Pakistan

  • School of dentistry

    Islamabad, Federal, 44000, Pakistan