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Dead teeth revived with pulp transplant in small trial

NCT ID NCT07258888

Disease control Sponsor: Kahramanmaras Sutcu Imam University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether transplanting pulp tissue from a healthy tooth into a dead one could restore vitality. Twenty-one adults with dead single-rooted teeth received either a pulp transplant, a pulp transplant with growth factors, or standard root canal treatment. The goal was to see if the treated teeth would respond to electrical stimulation, indicating nerve regrowth. Results are preliminary and more research is needed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
autologous dental pulp transplantation
What this could lead to
If it works, this could offer a way to restore feeling in dead teeth, avoiding root canals and keeping the tooth alive.
What could go wrong
This is a very small, early study with only 21 people. The procedure requires a healthy donor tooth, and long-term success is uncertain. Risks include pain, infection, or the transplant not working.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Nov 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-40 years * Presence of single-rooted permanent teeth diagnosed with: * Pulp necrosis or * Irreversible pulpitis with radiographic periapical lesions * Availability of a caries-free, periodontally healthy third molar suitable for donor pulp harvesting Good general health, with no systemic diseases -Ability to understand the study procedures and provide written informed consent Exclusion Criteria: * Multi-rooted teeth or teeth with complex canal anatomy * Systemic diseases or medical conditions that may affect wound healing (e.g., diabetes, immunosuppression) * Lack of a suitable donor third molar for pulp harvesting * Advanced periodontal attachment loss or active periodontal disease * Pregnancy or lactation * Recent use of antibiotics or anti-inflammatory drugs (\<1 month) * Inability or unwillingness to attend scheduled follow-ups

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulp revascularization Pulpal regeneration

Contacts and locations

Locations

  • ahramanmaraş Sütçü İmam University, Faculty of Dentistry

    Kahramanmaraş, onikişubat, 46010, Turkey (Türkiye)

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