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Ozone may soothe cancer Patients' painful mouth sores

NCT ID NCT07638904

Symptom relief Sponsor: University of Pavia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked back at medical records of 58 adult cancer patients who developed painful mouth sores from chemotherapy or radiation. They had been treated with a combination of ozone applied in the dentist's chair and ozone-based gels, toothpaste, and mouthwash at home. The goal was to see how quickly the sores healed and whether pain improved. Because this was a small review of past cases with no comparison group, the findings are only hints, not proof.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozone therapy (chairside ozone application and ozonized oral care products)
What this could lead to
If results are positive, this could point toward a simple, non-drug option to ease painful mouth sores during cancer therapy.
What could go wrong
This is a small, retrospective study with no control group, so results are only suggestive. It cannot prove ozone therapy works better than standard care or no treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

58 people

The number who actually took part.

Started

Nov 2023

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult oncological patients with cancer therapy-related oral mucositis whose clinical data are already available in medical records and/or clinical documentation. Patients were previously managed in routine clinical practice for oral mucositis occurring during radiotherapy and/or chemotherapy. The study population includes patients with documented oral mucositis grade 1 or higher according to the World Health Organization Oral Toxicity Scale and available baseline and follow-up assessments of oral mucositis severity and oral pain intensity. No prospective enrollment, treatment assignment, or study-specific intervention will be performed.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Oncological patients undergoing radiotherapy and/or chemotherapy * Clinical diagnosis of cancer therapy-related oral mucositis grade 1 or higher according to the World Health Organization Oral Toxicity Scale * Availability of clinical documentation including World Health Organization Oral Toxicity Scale assessments and Visual Analogue Scale pain scores at baseline and at one or more follow-up timepoints * Availability of relevant demographic and clinical information required for the retrospective analysis Exclusion Criteria: * Age younger than 18 years * Absence of a documented diagnosis of cancer therapy-related oral mucositis * Incomplete or unavailable clinical documentation for the primary and/or main secondary outcome * Missing baseline World Health Organization Oral Toxicity Scale assessment * Missing baseline Visual Analogue Scale pain assessment * Any condition making the available data unsuitable for retrospective analysis

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Conditions

The condition(s) this trial relates to.

chemotherapy-induced oral mucositis stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral mucositis

Contacts and locations

Locations

  • Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia

    Pavia, Lombardy, 27100, Italy

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