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Scientists track germs in root canals during standard dental care

NCT ID NCT07623278

Knowledge-focused Sponsor: Hasanuddin University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how the types of bacteria in an infected root canal change during routine dental treatment. Twenty-four adults with a chronic tooth abscess received standard root canal therapy using one of two bleach solutions (5.25% or 3% sodium hypochlorite) followed by a medicated filling (calcium hydroxide). Researchers took samples before, during, and after treatment to analyze the bacterial community. The goal was simply to understand the bacterial changes, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

Oct 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult aged between 18 and 75 years. * Physically and mentally able to undergo treatment * Have not used antibiotics within 1 week before treatment. * Permanent molar teeth showing clinical and radiographic signs of chronic apical abscess and considered restorable. * Willing to participate in the study and able to provide written informed consent after receiving an explanation of the study. Exclusion Criteria: * Systemic conditions that require antibiotic prophylaxis for routine dental treatment or other significant systemic disease. * Pregnant or breastfeeding women. * Participants with cognitive impairment. * Teeth with advanced mobility (greater than grade 2). * Teeth with periodontal pockets deeper than 4 mm. * Teeth with radiographic signs of root resorption. * Teeth with calcification or obliteration of the root canal. * Teeth with root fracture or that fracture during treatment. * Teeth with open apices.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis dental abscess suppurative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic apical abscess Root canal infection

Contacts and locations

Locations

  • Dental and Oral Hospital Hasanuddin University

    Makassar, South Sulawesi, 90245, Indonesia

More trials for these conditions

Other studies related to the condition(s) this trial covers.