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Root canal battle: which medicament kills more bacteria?

NCT ID NCT07671326

Disease control Sponsor: Medipol University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests two different medicines placed inside root canals to kill bacteria in teeth with chronic infection. 24 adults with infected molars will receive either a bioceramic or a calcium hydroxide paste. Researchers measure bacterial levels before and after treatment to see which works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bio-C Temp (bioceramic) and UltraCal XS (calcium hydroxide)
What this could lead to
If one medicament proves more effective at killing bacteria, it could improve success rates for root canal treatments and reduce the need for retreatment.
What could go wrong
This is a small, early-stage study with only 24 participants, so results may not apply to all patients. The outcome is based on bacterial levels, not long-term tooth survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 18 and 65 years * Being systemically healthy (ASA I or ASA II) * Mandibular molar teeth with a radiographically detectable radiolucent lesion in the periapical region * Willingness of the volunteer or their legal representative to participate in the study by signing the Informed Consent Form Exclusion Criteria: * Patients who have received antibiotics or corticosteroids within the last 3 months * Patients with systemic diseases * Teeth that cannot be properly isolated with a rubber dam * Teeth with periodontal pockets \>4 mm and teeth with crown/root fractures * Individuals who are undergoing or planning to start orthodontic treatment during the study period * Pregnant or breastfeeding individuals

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis dental abscess periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intracanal medicaments Periapical periodontitis Root canal infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Istanbul Medipol University

    RECRUITING

    Istanbul, Istanbul, 34230, Turkey (Türkiye)

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