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Dead tooth brought back to life? new pilot study shows promise

NCT ID NCT07314866

Disease control Sponsor: Kahramanmaras Sutcu Imam University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small pilot study tested a new way to treat dead (necrotic) teeth in 6 adults. Doctors took pulp tissue from a healthy donor tooth, mixed it with a growth factor concentrate (CGF), and transplanted it into the dead tooth. After 12 months, they checked if the tooth regained feeling and if the bone around the root healed. The goal was to see if this approach could restore tooth health and avoid root canal treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

6 people

The number who actually took part.

Started

Jan 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy patients aged 15 to 40 years. * Mature permanent single-rooted teeth with clinical and radiographic diagnosis of pulp necrosis (or irreversible pulpitis with necrotic findings) associated with periapical radiolucency. * Probing depth \< 3 mm and no abnormal tooth mobility. * No previous endodontic treatment or apical surgery on the study tooth. * Availability of an autologous donor tooth (impacted or nonfunctional third molar indicated for extraction) to obtain pulp tissue. * Ability and willingness to attend follow-up visits and provide written informed consent. Exclusion Criteria: * Systemic conditions that may impair healing (e.g., uncontrolled diabetes mellitus, autoimmune disease) or use of immunosuppressive therapy. * History of head and neck radiotherapy. * Pregnancy or lactation. * Poor oral hygiene or periodontal disease with probing depth ≥ 4 mm. * Teeth with root fracture, internal/external root resorption, severe canal calcification, or non-restorable crown destruction. * Inability to comply with follow-up schedule.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Pulp necrosis Pulp necrosis with periapical periodontitis Regenerative treatment of pulp necrosis in mature permanent teeth

Contacts and locations

Locations

  • Kahramanmaraş Sutcu İmam University, Faculty of Dentistry

    Kahramanmaraş, onikişubat, 46010, Turkey (Türkiye)

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