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Root canal showdown: one visit or two? new study has answers

NCT ID NCT07354373

Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a root canal for an infected tooth with an abscess can be done in one visit instead of two. Fifty-nine adults received either a single-visit treatment or a two-visit treatment with a calcium hydroxide medication placed in between. After 12 months, both groups showed similar healing of the infection on X-rays and CT scans. The findings suggest that a single visit may be just as effective, potentially saving patients time and extra appointments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Calcium hydroxide (interim medication)
What this could lead to
If successful, this could show that a single root canal visit is as effective as two visits, saving time and reducing patient discomfort.
What could go wrong
This is a small, completed study with only 59 participants. Results may not apply to all patients, and the treatment is already standard care, so no major breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

59 people

The number who actually took part.

Started

Sep 2021

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Classified as American Society of Anesthesiologists (ASA) Class I or II * presenting with radiographic evidence of apical periodontitis-defined as a Cone-Beam Computed Tomography Periapical Index (CBCTPAI) score of 3 or greater according to the Estrela classification Exclusion Criteria: * Exclusion criteria included patients with uncontrolled chronic systemic conditions (e.g., diabetes, hypertension, chronic obstructive pulmonary disease), cardiovascular disease, renal or hepatic impairment, and autoimmune disorders * History of smoking * Periodontal disease with probing depths ≥ 3 mm. * Root fractures * Immature apices * Resorption * perforations * Inability to achieve rubber dam isolation * Lack of informed consent

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Conditions

The condition(s) this trial relates to.

dental pulp disorder periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endodontic infection Periapical periodontitis

Contacts and locations

Locations

  • University of California San Francisco School of dentistry

    San Francisco, California, 94143, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.