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Laser or ozone: which eases cancer mouth sores best?

NCT ID NCT07069153

Symptom relief Sponsor: University of Pavia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two treatments—laser therapy and ozone gas—to relieve painful mouth sores caused by cancer treatment. Forty adults with head and neck or blood cancers took part. Each received one treatment daily for five days. The goal was to see which therapy better reduced soreness and improved quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jul 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Diagnosis of head and neck cancer or hematologic malignancy * Currently undergoing chemotherapy and/or radiotherapy * Presence of oral mucositis of grade 2 or higher (WHO Oral Mucositis Scale) * Ability to provide written informed consent * Willingness to comply with study procedures and follow-up schedule Exclusion Criteria: * Presence of autoimmune or systemic diseases affecting the oral mucosa (e.g., lichen planus, pemphigus, pemphigoid) * Presence of active oral infections unrelated to mucositis (e.g., candidiasis, herpes simplex) * Previous treatment with ozone or laser therapy for oral mucositis in the past 3 months * Pregnancy or breastfeeding * Cognitive impairment or psychiatric disorders preventing full cooperation * Known allergy or intolerance to ozone or laser exposure * Use of investigational drugs or participation in other clinical trials within 30 days prior to enrollment

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Conditions

The condition(s) this trial relates to.

Cancer Pain head and neck cancer head and neck neoplasm Head and Neck Neoplasms hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck neoplasms Hematologic neoplasms Oral mucositis

Contacts and locations

Locations

  • Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia

    Pavia, Lombardy, 27100, Italy

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