HEMATOLOGIC NEOPLASMS

This study tests three different flu vaccines in 60 adults with blood cancers like leukemia or lymphoma, including those who had a stem cell transplant or CAR-T therapy. The goal is to see which vaccine triggers the strongest immune response. Results will help doctors choose the …

This study tests whether giving donor immune cells (lymphocytes) soon after a stem cell transplant can lower the chance of blood cancer coming back. Adults aged 18-65 with high-risk leukemia, lymphoma, or similar cancers are eligible. Participants receive chemotherapy, a stem cel…

This study is for adults aged 18-85 with blood cancers that haven't responded well to standard treatments. It tests whether a lower dose of the drug cyclophosphamide, given after a bone marrow transplant, can reduce side effects while still preventing graft-versus-host disease (G…

This study tests whether red blood cells stored with less oxygen (hypoxic RBCs) are safer and more effective than standard blood for people with blood cancers who need regular transfusions. About 24 adults with transfusion-dependent blood cancers will receive both types of blood …

This study tests giving a special immune cell treatment (CAR T-cells) together with a half-matched bone marrow transplant for people with aggressive blood cancers like leukemia and lymphoma. The goal is to see if this combination is safe and can help prevent the cancer from comin…

This study tests whether giving a drug called tranexamic acid (TXA) along with platelet transfusions only when needed is safer and works better than giving platelet transfusions preventively. About 662 adults with blood cancers who are getting their own stem cells transplanted wi…

This study tests whether a mind-body group program can help reduce fatigue in people who have finished treatment for blood cancers like leukemia or lymphoma. About 94 participants in remission will be randomly assigned to the program or usual care. The goal is to see if this supp…

This study looks at whether a computer brain-training program called Lumosity can help improve memory and thinking in people who have had a stem cell transplant for blood cancer. About 60 adults who are 3 to 6 months post-transplant will either start training right away or wait 1…

This study looks at how cancer impacts the health and well-being of both patients and their family caregivers. Researchers will survey 240 Danish adults with breast, prostate, colorectal cancer, or lymphoma, along with their chosen caregivers. The goal is to identify families who…

This study uses advanced genetic testing (next generation sequencing) to look for early warning signs of pre-myeloid cancers and bone marrow failure in 2000 people. Participants have certain blood abnormalities or genetic markers that may increase their risk. The goal is to bette…

This study enrolls up to 10,000 adults with cancer to see how often doctors follow recommendations from a special team called the Precision Medicine Molecular Tumor Board. The team reviews each patient's genetic test results to suggest personalized treatments. Researchers will tr…

This study collects blood, bone marrow, urine, and tissue samples from people with cancer or blood disorders, as well as from their healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, improve treatments, and find ne…