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Can smoking alter blood vessel proteins in your gums?

NCT ID NCT07765251

Knowledge-focused Sponsor: Inonu University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study looks at how smoking affects proteins linked to blood vessel formation in gum disease. Researchers will measure levels of KLF2, FBXW7, and other markers in fluid from around the teeth and in saliva from adults who are smokers or non-smokers, with healthy gums, gingivitis, or periodontitis. The goal is to understand the connection between smoking, gum inflammation, and blood vessel health in the mouth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this research succeeds, it could reveal how smoking worsens gum disease through blood vessel changes, potentially pointing to new ways to prevent or treat gum problems in smokers.
What could go wrong
This is an observational study measuring protein levels, not a treatment trial. It may not prove cause and effect, and results might not apply to everyone with gum disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

114 people

The number who actually took part.

Started

Mar 2024

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 18 to 65 years attending the periodontology clinic were enrolled and classified into 6 groups based on clinical periodontal parameters and smoking status according to the 2017 World Workshop classification: periodontal health, gingivitis, and periodontitis (Stage III Grade B). Exclusion criteria included any systemic disease, regular medication use, pregnancy or lactation, periodontal treatment within the past 6 months, antibiotic use within the past 6 months, and presence of prosthetic restorations on the teeth to be sampled. A total of 114 participants (19 per group; 56 males, 58 females) were included.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion criteria for the Healthy Control group: * presence of ≥ 20 teeth in the mouth * probing pocket depth (PPD) ≤ 3 mm * the percentage of bleeding sites for the whole mouth \< 10%, * on radiographic examination, a distance of ≤ 3 mm between the cemento-enamel junction and the alveolar bone crest in 95% of all teeth. Inclusion criteria for the Gingivitis group were * presence of ≥ 20 teeth in the mouth * PPD ≤ 3 mm, -% of bleeding sites for the whole mouth ≥ 10%, * on radiographic examination, a distance of ≤ 3 mm between the cemento-enamel junction and the alveolar bone crest in 95% of all teeth. Inclusion criteria for the Stage 3 Periodontitis group * presence of ≥ 15 teeth in the mouth * more than 30% of teeth affected by periodontal disease * affected teeth exhibiting probing depths of 6 mm or more * clinical attachment loss (CAL) of ≥ 5 mm, * vertical bone loss of 3 mm or more * class 2 or 3 furcation involvement * radiographic evidence of alveolar bone loss extending to the middle third and beyond (33%) in the relevant teeth Exclusion Criteria: * presence of any systemic disease * regular use of any medication * pregnancy or lactation * periodontal treatment within the last 6 months * antibiotic use within the last 6 months * the presence of prosthetic restorations on the teeth to be sampled

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Conditions

The condition(s) this trial relates to.

gingivitis periodontitis Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis

Contacts and locations

Locations

  • Inonu University, Faculty of Dentistry, Deparment of Periodontology

    Malatya, 44100, Turkey (Türkiye)

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