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Light-Activated therapy boosts root canal disinfection?

NCT ID NCT07666932

Disease control Sponsor: Bayan Alqrenawi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with photodynamic therapy. Bacterial levels were measured before and after treatment to see which method reduced germs more.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sodium hypochlorite and photodynamic therapy (photosensitizing agent plus light)
What this could lead to
If it works, this could point toward a more effective way to disinfect root canals, reducing infection and pain after treatment.
What could go wrong
This is a small, completed study with only 64 participants. Results may not apply to all patients or tooth types, and photodynamic therapy adds time and cost.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

May 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 to 70 years. * Medically healthy patients or patients with well-controlled systemic conditions, such as controlled diabetes or controlled hypertension. * Patients requiring primary root canal treatment in mature, single-rooted, single-canal teeth. * Teeth with a confirmed diagnosis of pulp necrosis, with or without apical periodontitis. * Teeth that are restorable. * Teeth suitable for single-visit root canal treatment. * Teeth suitable for rubber dam isolation. * Cases with dry canals that do not require inter-appointment medication. * Participants who provide written informed consent before treatment. Exclusion Criteria: * Patients with uncontrolled systemic disease. * Patients with immunocompromised status. * Patients with any condition that could affect infection, healing, or treatment response. * Patients who used systemic antibiotics within the previous three months. * Patients who used analgesic or anti-inflammatory medication shortly before treatment. * Pregnant or lactating patients. * Patients with known allergy or contraindication to any study material. * Teeth with irreversible pulpitis. * Teeth with previous root canal treatment or retreatment indication. * Teeth with immature apices. * Teeth with internal or external root resorption. * Teeth with cracks, fractures, or perforations. * Teeth with unusual canal anatomy that could prevent procedural standardization. * Teeth with advanced periodontal involvement. * Teeth with unrestorable coronal structure. * Canals with persistent exudate. * Cases with acute swelling or acute abscess. * Any condition requiring multi-visit treatment.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Dental pulp necrosis

Contacts and locations

Locations

  • University of Jordan

    Amman, Jordan

More trials for these conditions

Other studies related to the condition(s) this trial covers.