Tooth-Saving showdown: which pulp capping material wins?
NCT ID NCT07562555
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two materials, ProRoot MTA and Biofactor MTA, for direct pulp capping—a procedure to save a tooth's nerve after exposure. Eighty permanent teeth were treated, and patients reported pain levels for 48 hours. Success was checked at 6 and 12 months by looking for symptoms like pain or swelling and X-ray signs of infection. The goal was to see if Biofactor MTA works as well as the standard ProRoot MTA.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ProRoot MTA and Biofactor MTA (calcium silicate-based materials used in dental procedures)
- What this could lead to
- If successful, this could show that Biofactor MTA is as effective as ProRoot MTA for preserving tooth vitality, offering a reliable alternative for dental pulp therapy.
- What could go wrong
- This is a small, completed study with 80 participants, so results may not apply to all patients. Long-term success beyond 12 months is unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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13 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged between 13 and 65 years * Patients with adequate patient-clinician communication * Patients who agree to attend periodic follow-up visits throughout the study * Patients who provide written informed consent to participate in the study * Systemically healthy patients * Teeth with no previous endodontic treatment * Teeth showing a positive response to cold and electric pulp test * Permanent teeth * Posterior teeth * Teeth that can be restored with direct composite restoration * Teeth with pulp exposure (pulpal perforation) * Presence of bleeding from the exposed pulp that can be controlled within 5-10 minutes Exclusion Criteria: * Patients who refuse to participate in the study * Medically compromised patients (e.g., patients with systemic diseases, immunological disorders, or those using medications) * Patients with known allergies to materials used during vital pulp therapy * Pregnant patients * Non-vital teeth * Presence of advanced periodontal disease (probing depth \> 3 mm) * Teeth with previous endodontic treatment * Teeth with insufficient remaining tooth structure that cannot be restored with restorative materials * Teeth where adequate isolation cannot be achieved * Teeth requiring post core restoration * Patients in whom periapical radiographs cannot be obtained * Patients unable to attend follow-up visits * Cases in which bleeding from the exposed pulp cannot be controlled within 5-10 minutes
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ege University Faculty of Dentistry
Izmir, 35100, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.