Smokers who switch to 'Smokeless' nicotine may see healthier gums, study finds

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Demonstrate understanding of the study and willingness to participate in the study by providing a signed written informed consent * Healthy subjects, not taking regular medications for chronic medical conditions * Adults, age at least 18 years old. * Presence of at least 10 natural anterior teeth in total (cuspid to cuspid, lower and upper jaw). * Presence of at least 18 'scorable' teeth with scorable facial and lingual surfaces. Teeth that are grossly carious, orthodontically banded, exhibiting general cervical abrasion and/or enamel abrasion, and third molars will not be included in the tooth count; * Willingness and ability to comply with the requirements of the study including installing an APP on their digital device, e.g. smart phone or tablet. For Arms A and B, subject have to be: * Regular smokers, defined as: * Smoked for at least five consecutive years prior to Screening. * Smoked \>10 and \< 30 cigarettes per day (CPD). * with an exhaled breath carbon monoxide (CO) level ≥7 ppm at Screening. * willing to regularly use of any nicotine or tobacco product other than their own conventional cigarettes brand within 14 days prior to Screening. * willing to change to use of study products or if randomized to Arm A continuing to use their own brand of conventional cigarettes for the whole duration of the study. For Arm C, subjects have to be: * Never-smokers, defined as: * never smoked or who have smoked \< 100 cigarettes in their lifetime and none in the 30 days prior to screening. * with an exhaled breath CO level \< 7 ppm at screening. * willing to not smoke or use any form of tobacco or nicotine-containing products for the whole duration of the study. Exclusion Criteria: * Pregnancy. * Presence of extensive crown or bridge work, dental implants, and/or rampant decay (per Investigator/Examiner discretion) * Significant oral soft tissue pathology or any type of gingival overgrowth, other than plaque-induced gingivitis and mild periodontitis (Stage I) * Moderate to Severe Periodontitis (Stage II, III and IV) based on 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions, which require: * Detectable Interdental Clinical Attachment Loss (CAL) ≥ 3 mm at ≥ 2 non-adjacent teeth. * Buccal or Oral CAL ≥3 mm with pocketing ≥ 5 mm detectable at ≥ 2 teeth. * Removable dentures or fixed and removable orthodontic appliance (except fixed lingual wires). * Significant history of alcoholism or drug abuse (other than tobacco/nicotine) within 24 months prior to screening, as determined by the Investigator. * A course of treatment with any medications or substances (other than tobacco/nicotine) which: * interfere with the cyclooxygenase pathway (e.g. anti-inflammatory drugs including aspirin and ibuprofen) within 3 days prior to each visit. * are known to have antibacterial activity (e.g. antibiotics) within 7 days prior to each visit.