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New Tooth-Saving material could spare kids from extractions

NCT ID NCT07702942

Disease control Sponsor: Postgraduate Institute of Dental Sciences Rohtak Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This study tests whether a newer, easier-to-use material called NeoPUTTY works as well as the standard MTA for saving permanent back teeth with severe nerve inflammation in children aged 9 to 14. Both materials are used to cover the remaining healthy nerve after removing the diseased part, aiming to keep the tooth alive and avoid extraction. Forty-six children were randomly assigned to receive one of the two materials and were followed for a year to check for pain, infection, and healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NeoPUTTY (a premixed calcium silicate bioceramic material) and Mineral Trioxide Aggregate (MTA) used as pulp-capping materials after pulpotomy
What this could lead to
If NeoPUTTY works as well as MTA, it could offer a simpler, faster option for saving severely inflamed teeth in children, reducing the need for extractions.
What could go wrong
This is a small study with only 46 children, and results may not apply to all ages or tooth types. The long-term success of NeoPUTTY is still unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

46 people

The number who actually took part.

Started

May 2024

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

9 to 14 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy children aged 9 to 14 years with mature permanent maxillary or mandibular molars presenting with symptomatic irreversible pulpitis, characterized by spontaneous pain, lingering thermal pain, or referred pain of moderate or severe intensity per Wolters classification * Teeth with complete root development and closed apices confirmed radiographically, with adequate remaining coronal tooth structure for definitive restoration * Deep or extremely deep carious lesions with risk of or unavoidable pulp exposure during operative treatment * Teeth with normal periapical radiographic appearance or mild periapical changes limited to slight widening of periodontal ligament space or subtle trabecular alterations without frank periapical radiolucency or loss of lamina dura continuity * Teeth free from advanced periodontal disease * Parents or legal guardians willing to provide written informed consent and comply with follow-up schedule Exclusion Criteria: * Children with systemic diseases or known hypersensitivity to any material used in the study * Teeth with immature root development or incomplete apical closure * Non-restorable teeth with inadequate remaining coronal tooth structure * Teeth with pathological mobility, sinus tract, or soft tissue swelling * Established apical periodontitis with frank periapical radiolucency, furcation involvement, or loss of lamina dura continuity on radiographic examination * Evidence of internal or external pathological root resorption * Failure to achieve haemostasis within 25 minutes of coronal pulp amputation * Lack of parental or guardian consent or unwillingness to comply with follow-up visits

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irreversible pulpitis Pulpotomy

Contacts and locations

Locations

  • Post Graduate Institute of Dental Sciences, Rohtak

    Rohtak, Haryana, 124001, India

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Other studies related to the condition(s) this trial covers.