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AI predicts dental numbing success in painful tooth condition

NCT ID NCT07672678

Knowledge-focused Sponsor: Jamia Millia Islamia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning approaches. The goal is to help dentists know ahead of time who might need extra numbing, making treatment more comfortable.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help dentists predict which patients might need extra numbing before treatment, reducing pain and anxiety.
What could go wrong
The models are based on data from one center and may not work for all patients. Also, machine learning predictions are not always accurate in real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

4,390 people

The number who actually took part.

Started

May 2014

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Consecutive adult patients (≥18 years) presenting for endodontic treatment with a clinical diagnosis of symptomatic irreversible pulpitis at a single dental teaching institution (Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India) from May 2014 to October 2025.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (≥18 years) presenting with a clinical diagnosis of symptomatic irreversible pulpitis in a permanent tooth * Diagnosis confirmed on the basis of patient-reported symptoms (spontaneous pain, lingering pain to thermal stimuli), clinical examination, and positive pulp sensibility testing (cold test and/or electric pulp test) * Absence of radiographic evidence of periapical pathology * ASA physical status I or II * No prior local anesthetic injection for the same tooth within the preceding 24 hours * No documented allergy or contraindication to amide local anesthetics Exclusion Criteria: * ASA physical status classification III or higher * Pregnancy * Confirmed radiographic periapical lesion or diagnosis of pulp necrosis * Prior local anesthetic injection for the same tooth within the preceding 24 hours * Documented allergy or contraindication to amide local anesthetics * Age under 18 years * Records with missing key predictor or outcome variables (9.2% of initially screened records excluded)

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia, local Nerve block Pulpitis

More trials for these conditions

Other studies related to the condition(s) this trial covers.