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Could opioid tolerance dull the power of local anesthetics?

NCT ID NCT06488768

Knowledge-focused Sponsor: Charlotte Runge Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study asks whether people who take opioids daily experience shorter-lasting nerve blocks for pain relief. Researchers will give a radial nerve block to 20 opioid-tolerant individuals and 20 matched opioid-naive volunteers, then measure how quickly the block starts and how long it lasts. The goal is to see if opioid tolerance reduces the effectiveness of local anesthetics, which could inform better pain management strategies for this group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
radial nerve block with lidocaine 2%
What this could lead to
If opioid tolerance shortens nerve blocks, this could lead to tailored pain management plans for people on long-term opioids, ensuring better postoperative pain relief.
What could go wrong
This is a small, early-stage study with only 40 participants, so results may not apply broadly. Individual differences in pain perception and nerve anatomy could also affect outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jun 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 84 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for opioid group * Age \> 18 years old * ASA 1-3 * Chronic pain, defined as persisting pain for more than three months * Daily use of more than 60 mg of morphine equivalent in more than 7 days * Legally competent and able to give informed consent Inclusion criteria for the opioid naive control group * Age \> 18 years old * ASA 1-3 * No use of opioids within 30 days prior to participation * Legally competent and able to give informed consent Exclusion Criteria: * Age \> 84 years old * Volunteers who cannot cooperate with the study * Volunteers who cannot understand or speak Danish * Allergy to the lidocaine or the preservatives used in the study * Alcohol or drug abuse other than opioids * Peripheral neuropathy at the upper limb non-dominant arm * Pathology or previous major surgery to the upper limb * Active signs of infection in the cutaneous area of injection * Pregnancy at the time of the trial * Partial or complete 2nd or 3rd degree atrioventricular heart block without a pacemaker * Severe liver disease * Severe kidney disease and reduced kidney function (eGFR below 30 mL/min) * Daily treatment with drugs that are structurally related to local analgesics or class IB antiarrhythmics, as the toxic effects are additive * Daily treatment with class III antiarrhythmics e.g., amiodarone.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nerve block Opioid tolerance

Contacts and locations

Locations

  • Silkeborg Regional Hospital

    Silkeborg, Silkeborg, 8600, Denmark

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