Could opioid tolerance dull the power of local anesthetics?
NCT ID NCT06488768
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This study asks whether people who take opioids daily experience shorter-lasting nerve blocks for pain relief. Researchers will give a radial nerve block to 20 opioid-tolerant individuals and 20 matched opioid-naive volunteers, then measure how quickly the block starts and how long it lasts. The goal is to see if opioid tolerance reduces the effectiveness of local anesthetics, which could inform better pain management strategies for this group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radial nerve block with lidocaine 2%
- What this could lead to
- If opioid tolerance shortens nerve blocks, this could lead to tailored pain management plans for people on long-term opioids, ensuring better postoperative pain relief.
- What could go wrong
- This is a small, early-stage study with only 40 participants, so results may not apply broadly. Individual differences in pain perception and nerve anatomy could also affect outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NERVE BLOCK are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Silkeborg Regional Hospital
Silkeborg, Silkeborg, 8600, Denmark
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could muscle loss weaken the power of nerve blocks?
- Which nerve block offers better pain relief for kidney donors?
- Can a new nerve block cut opioid use after lung surgery?
- Nerve block may slash opioid use after kidney surgery
- Study investigates whether more nerve blocks mean better recovery for polytrauma patients
- AI predicts dental numbing success in painful tooth condition