Can a new nerve block cut opioid use after lung surgery?

NCT ID NCT07745881

Symptom relief Sponsor: Nanjing First Hospital, Nanjing Medical University Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This trial tests whether a newer ultrasound-guided nerve block, called retro-SCTLB, provides better pain relief after minimally invasive lung cancer surgery than the standard thoracic paravertebral block. Adults aged 18-80 scheduled for thoracoscopic lung cancer removal will be randomly assigned to receive one of the two blocks before surgery. Researchers will measure the total opioid pain medication needed in the first 24 hours after surgery, as well as pain scores over the next two days, to see if the newer block reduces opioid use and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Ultrasound-guided retro-superior costotransverse ligament space block (retro-SCTLB) compared to thoracic paravertebral block (TPVB)
What this could lead to: If effective, this nerve block could offer better pain relief after lung surgery, reducing the need for opioids and their side effects.
What could go wrong: This is a single trial with a specific patient group, so results may not apply broadly. The procedure carries risks like infection or nerve damage, and it may not prove superior to the existing block.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 130 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for thoracoscopic radical lung cancer surgery under general anesthesia； * aged 18-80 years； * BMI 18-30 kg/m²； * ASA classification I-III； Exclusion Criteria: * Allergy to the study drug or local anesthetic; * History of opioid abuse; * Pre-existing skin infection at the puncture site of ITPN or TPVB; * Peripheral infectious neuropathy; * Dysfunction of blood coagulation;

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Conditions

The condition(s) this trial relates to.

lung cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nerve block Thoracoscopic radical resection of lung cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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Can a new nerve block cut opioid use after lung surgery?

What the study statuses mean