Mouthwash showdown: which rinse best fights gum disease?
NCT ID NCT07031388
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested four different mouthwashes—hydrogen peroxide with hyaluronic acid, hyaluronic acid alone, chlorhexidine, and a placebo—in 80 healthy adults aged 18 to 35 with mild gum inflammation. Participants used their assigned rinse twice daily for three weeks. The goal was to see which one best reduced gum inflammation, plaque, and bleeding. Results could help people choose an effective mouthwash to manage gingivitis and prevent it from progressing.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hydrogen peroxide, hyaluronic acid, chlorhexidine mouthwashes
- What this could lead to
- If successful, this could identify an effective mouthwash to manage gingivitis and prevent it from worsening into more serious gum disease.
- What could go wrong
- This is a small, completed trial with 80 participants, so results may not apply to everyone. Mild side effects like taste changes or discomfort are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80 people
The number who actually took part.
- Started
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Jul 2025
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 35 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subjects with a gingival index score of 1 or greater. * Subjects with a plaque index score of 1 or greater * Systemically healthy individuals. * Minimum of 20 natural teeth Exclusion Criteria: * Current use of any mouthwash. * Smoking habit. * Presence of active caries. * Overhanged restorations and crowns. * Presence of supra or subgingival calculus. * Ongoing orthodontic treatment (including post-treatment retainer) * Periodontal treatment within the past 6 months and a diagnosis of periodontitis. * Use of antibiotics within the past 4 months or requirement for antibiotic prophylaxis. * Systematic or topical non-steroidal anti-inflammatory drug treatment for the past 4 months * Pregnancy or lactation. * History of heart valve replacement. * Known intolerance or allergy to mouth rinses.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
khanzad specialized health centre + Hwler dental center + Azadi dental center + Students of Hawler medical college
Erbil, Kurdistan, 00441, Iraq
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