Mouth disorder

This trial tests whether transplanting a patient's own minced pulp tissue into a cleaned root canal can regenerate living dental pulp. Fifty participants aged 7 to 50 with infected or inflamed teeth will receive either standard root canal treatment or the experimental tissue tran…

This study tests whether adding the experimental drug ipatasertib to the standard immunotherapy pembrolizumab works better than pembrolizumab alone for people with head and neck cancer that has returned or spread. About 52 adults with incurable, advanced squamous cell carcinoma w…

This study looks at whether a toothpaste with a special gum-health ingredient can improve gum health in people with gingivitis. 150 adults will use the test toothpaste for 13 weeks, then switch to a regular fluoride toothpaste for 4 weeks. Researchers will measure gum inflammatio…

Researchers are testing an experimental antibody called ONC-392 in people with advanced solid tumors, including non-small cell lung cancer and melanoma. The trial gives ONC-392 alone or with pembrolizumab, an approved immunotherapy, to see what doses are safe and how the body pro…

This phase III trial compares the standard immunotherapy drug pembrolizumab alone versus pembrolizumab plus radiation therapy in 290 patients with metastatic head and neck cancer. The goal is to see if adding radiation improves overall survival. Participants receive pembrolizumab…

This trial tests two treatments for dry socket, a painful complication after tooth extraction. One is Alvogyl, a standard medicated dressing. The other is platelet-rich fibrin (PRF), made from the patient's own blood, which may help tissue heal. About 102 adults with dry socket w…

Researchers are testing a shorter radiation schedule for people with head and neck cancer who have had surgery. Standard radiation after surgery often takes several weeks, but this trial gives five treatments over five days. The study enrolls 50 adults with high-risk features, su…

This trial tests whether a toothpaste containing arginine can alter the bacteria living below the gumline in people with gum disease who are already receiving ongoing dental care. Participants will brush twice daily for six months with either an arginine toothpaste or a standard …

This study tests an experimental drug called IMVT-1402 in 180 adults with moderate to severe Sjögren's disease. Participants receive either the drug or a placebo as a weekly injection under the skin for 24 weeks. The goal is to see if the drug can reduce overall disease activity …

This early-phase trial is testing a combination of two drugs—trastuzumab deruxtecan (a targeted chemotherapy) and ceralasertib (a drug that may block cancer cell repair)—in people with advanced solid tumors that have a HER2 mutation. The study has two parts: first, finding the sa…

This early-phase study tests a personalized cell therapy (rapcabtagene autoleucel) in 27 adults with difficult-to-treat rheumatoid arthritis or severe Sjogren's disease. The treatment uses a patient's own immune cells, modified to target and calm the overactive immune system. The…

This study tests whether simple text messages and online activities can encourage people with Type 2 Diabetes to get more preventive dental care, like cleanings, instead of waiting for expensive treatments. Researchers will track dental insurance claims from 10,000 adults over 18…

This trial tests whether adding weekly thermotherapy, a treatment that heats the tumor and lymph nodes, to standard radiotherapy can help people with head and neck cancer who cannot receive chemotherapy. The goal is to find a safe dose of thermotherapy that does not cause severe …

This trial tests whether a collagen matrix can match the standard tissue graft for improving gum shape around a single dental implant in the front upper jaw. Thirty adults with one missing tooth will receive an implant and then either a graft taken from their palate or a collagen…

This study compares standard radiation plus cisplatin against two experimental approaches: radiation with docetaxel and cetuximab, or radiation with cisplatin and the immunotherapy drug atezolizumab. About 613 patients with high-risk stage III-IV head and neck cancer will partici…

This study tests whether baricitinib, a drug used for arthritis, can help people with moderate to severe oral lichen planus—a painful mouth condition. Ten adults who haven't improved with other treatments will take the drug for six months. Researchers will measure changes in mout…

This study compares a new cleaning solution made from ferumoxytol nanozymes to the standard treatment for root canal infections. About 72 adults with infected teeth will receive either the new solution or the usual one during their root canal procedure. Researchers will measure h…

This study tests whether a combination of two hormone-blocking drugs (apalutamide and a GnRH agonist) can shrink or slow the growth of advanced salivary gland cancer that has a specific protein called the androgen receptor. About 31 adults with locally advanced or spread cancer t…

This phase 3 trial tested whether adding bevacizumab to standard chemotherapy helps people with head and neck cancer that has returned or spread. About 403 adults took part. The main goal was to see if the combination improved overall survival compared to chemotherapy alone.

This phase 3 trial tests whether nipocalimab can safely reduce disease activity in adults with moderate to severe Sjogren's disease. About 655 participants receive either nipocalimab or a placebo, along with standard care, for 48 weeks. The main goal is to see if the drug improve…

This trial tests whether cocoa husk, a byproduct of chocolate production, can reduce pain and bacteria after root canal treatment. Researchers will compare three approaches in 36 adults with a dead nerve in a lower molar: standard calcium hydroxide, cocoa husk alone, or a mix of …

This trial evaluates a modified surgical technique called the vertically coronally advanced flap (V-CAF) combined with a connective tissue graft and tissue regeneration materials to treat gum recession. It focuses on people with Miller Class III recession, a more severe form wher…

This phase 2 study tests the drug entrectinib in over 500 people with advanced solid tumors that have specific gene changes (NTRK, ROS1, or ALK fusions). The goal is to see if the drug can shrink tumors and control the disease. Participants have various cancer types, including lu…

This trial compares two dental procedures for treating severe, irreversible pulpitis (nerve inflammation) in baby molars of healthy children. One group receives a pulpotomy using MTA, a less invasive procedure that removes only the infected pulp from the crown. The other receives…

This study tests whether a special wipe containing xylitol, a natural sweetener, can reduce dangerous bloodstream infections in children and young adults undergoing stem cell transplants. These infections often start from bacteria in the mouth and can be life-threatening. Partici…

This phase I trial is testing whether a combination of three treatments — an experimental drug called elimusertib, precise radiation therapy, and the immunotherapy pembrolizumab — can shrink or stabilize recurrent head and neck cancer that cannot be removed by surgery. The study …

This phase 3 study tests the long-term safety of ianalumab in 612 people with Sjögren's syndrome who already completed a year of treatment in earlier trials. Participants receive ianalumab or placebo injections for up to several more years. The goal is to see if the drug remains …

This study compares two conservative methods for treating deep tooth decay that reaches close to the nerve. In one approach, dentists leave softer decayed tissue near the nerve; in the other, they remove more until firmer tissue remains. About 100 patients with deep decay in perm…

This trial compares two ways to treat a severely decayed tooth that has caused irreversible pulpitis, a painful condition where the tooth's inner pulp is inflamed. One method uses a standard solution to control bleeding after removing damaged pulp, while the other uses a diode la…

This trial tests whether a less invasive dental procedure called pulpotomy can successfully treat baby molars with a severe, painful tooth condition known as irreversible pulpitis. Instead of removing the entire nerve, pulpotomy removes only the top part and places a soothing med…

This trial compares two surgical techniques for treating receding gums, a condition where the gum tissue pulls away from the teeth, exposing the roots. One technique is the standard coronally advanced flap, and the other is a newer vertical variation. Both are performed along wit…

This trial tests five different materials placed beneath composite fillings in back teeth to see which one best supports the filling and keeps it firmly attached. Adults needing a standard back-tooth filling will receive one of the five materials at random. Dentists will check th…

This study compares two dental procedures for treating severe pulpitis (tooth nerve inflammation) in children's baby molars. One is a standard full root canal treatment (pulpectomy), and the other is a less invasive option that removes only part of the nerve (pulpotomy). The goal…

This study looks at how the part of a dental crown that sits under the gums is shaped and whether that shape helps keep gums and bone healthy. Thirty people with gum disease who already have a dental implant will get a custom crown. Researchers will measure bone loss, gum thickne…

This study compares two ways to treat deep cavities in young permanent teeth without exposing the nerve. In selective excavation, the dentist removes only the outer decay and seals the tooth. In stepwise excavation, they place a temporary filling first and remove more decay a few…

This trial compares two dental procedures—direct pulp capping and partial pulpotomy—for treating permanent teeth with deep cavities that expose the pulp. Adults with deep caries and reversible pulpitis will be randomly assigned to one of the two procedures. The study will follow …

This study compares three materials used to treat deep cavities in children's baby molars: a standard dental cement (MTA), a bleeding-stopping liquid (ferric sulfate), and a new natural gel made from shellfish shells (chitosan). 165 children aged 5-8 will receive one of these tre…

This study tests whether the level of a specific inflammatory marker (MMP9) in the dental pulp can predict the success of a full pulpotomy, a procedure that removes the inflamed pulp from the crown of a tooth and seals it with a special material. Adults with deep cavities causing…

This trial tests whether applying a gel containing hyaluronic acid and chlorhexidine after a minimally invasive deep cleaning can improve gum healing in people with advanced periodontitis (stage III or IV). Participants receive either the deep cleaning alone or the cleaning plus …

This phase 2 trial is testing whether an experimental drug called 9-ING-41, when combined with the chemotherapy drug carboplatin, can help people with advanced or metastatic salivary gland cancer. The study aims to see if the combination can shrink tumors or slow their growth. Pa…

This early-phase trial tests a new drug called berzosertib (M6620) alongside standard chemotherapy (cisplatin) and radiation in people with advanced head and neck cancer that has spread to nearby tissues. The main goals are to find the safest dose and to see what side effects occ…

This phase 2 trial is testing two hormone-blocking drugs—darolutamide and leuprolide acetate—in 21 patients with advanced salivary gland cancer that has spread or returned. The cancer must have a protein called androgen receptor. The goal is to see if the combination can shrink t…

This trial tests whether placing a temporary crown immediately after a dental implant helps keep gum tissue stable compared to placing the implant alone. About 44 adults with a non-restorable front tooth will be randomly assigned to one of the two approaches. Researchers will mea…

This study tests a surgical procedure to cover exposed tooth roots on the tongue side of lower teeth. Twenty adults with gum recession will receive the surgery and be followed for up to 24 months. The main goal is to see how much root coverage is achieved at 6 months, along with …

This phase 2 trial tests whether it is safe to skip radiation on one or both sides of the neck that show no signs of cancer after surgery. The goal is to reduce side effects like dry mouth and trouble swallowing without increasing the chance of cancer returning. The study include…

This trial compares two marketed brands of silver diamine fluoride (SDF) to see which is more effective at stopping tooth decay in children aged 4 to 7. Both treatments are applied to cavities and leave a black stain. Researchers will follow the children for one year, checking wh…

This study compares a new calcium silicate-based sealer to the standard resin-based sealer for root canals in molar teeth. About 136 adults aged 18-65 with infected molars will receive one of the two sealers. The goal is to see which material leads to better healing and fewer sym…

This study tests whether a less invasive partial pulpotomy works as well as the standard full pulpotomy for treating deep cavities in children's baby molars. Both procedures use MTA, a material that helps heal the tooth's pulp. The trial enrolls healthy children aged 4-8 with mat…

This trial tests whether coating clear orthodontic aligners with nano chitosan—a natural antimicrobial—can reduce white spot lesions (early enamel damage) that sometimes develop during aligner therapy. About 53 people with mild to moderate misalignment will wear either coated or …

This study is testing whether a precise form of radiation called proton therapy can control head and neck cancer after surgery as well as standard X-ray radiation, but with fewer side effects. About 174 adults with newly diagnosed head and neck cancer will receive either proton t…

This trial tests whether custom-made zirconia crowns hold up better than prefabricated ones in children's first permanent molars. Fifty children with badly decayed or damaged molars will receive one type of crown, and researchers will track retention, chipping, gum health, and fi…

This study investigates whether injecting Botox a few days before modified lip repositioning surgery helps prevent the return of a gummy smile (excessive gum display when smiling) within one year. Twenty adults with a gummy smile and hyperactive upper lip will be enrolled. The tr…

This phase 1 study tests whether adding a highly targeted, high-dose radiation boost (stereotactic body radiotherapy, or SBRT) to standard radiation and chemotherapy can safely treat head and neck cancer that has come back or spread. The trial includes two groups: patients whose …

This study tests a new drug called APG-115, alone or with chemotherapy, in people with a certain type of salivary gland cancer that has a normal p53 gene. The goal is to see if the drug can shrink tumors and to find the best dose with acceptable side effects. About 41 adults with…

This phase 2 trial tests a weekly combination of two chemotherapy drugs (carboplatin and paclitaxel) plus the immunotherapy pembrolizumab in 31 patients with metastatic head and neck cancer who cannot receive the standard drug 5-fluorouracil. The goal is to see if this regimen sh…

This study tests a combination of hormone therapy (goserelin) and an immunotherapy drug (pembrolizumab) in 20 people with advanced salivary gland cancer that cannot be removed by surgery or radiation. The goal is to see if the treatment shrinks tumors or slows the disease. Partic…

This study compares two types of prefabricated crowns—zirconia and Bioflx—for restoring decayed or discolored front baby teeth in children aged 3 to 5. Each child receives one crown type, and researchers track gum health, plaque buildup, wear on the opposite tooth, crown retentio…

This study compares four types of tooth fillings for cavities on the sides of back teeth. Three of the fillings release minerals like calcium and phosphate, which may help repair the tooth and prevent further decay. The fourth is a standard bulk-fill filling used for comparison. …

This study compares two treatments for infected baby molars in children aged 3 to 8: a less invasive method using a triple antibiotic paste versus a standard root canal with a calcium hydroxide-iodoform paste. The goal is to see which approach better relieves pain, swelling, and …

This study tests a new heat-resistant calcium silicate-based sealer used during root canals in people with infected tooth roots (apical periodontitis). The sealer is applied with different filling techniques to see if it improves bone healing and reduces pain after treatment. Par…

This pilot study tests a new surgical technique called the anterolateral thigh myofascial fat composite flap (ALT-MF) for repairing tongue defects after cancer surgery in obese patients (BMI 30 or higher). Traditional flaps can be too bulky in obese patients, leading to problems …

This study tests whether 3D-printed composite resin fillings work as well as semi-direct composite resin fillings for cavities or damaged back teeth. About 60 adults aged 25 to 40 who need two similar fillings will get one of each type. Researchers will check for cracks, wear, an…

This study tests two methods of placing a bulk-fill composite filling material in cavities on the chewing surfaces of back teeth. One method places the material all at once, while the other builds it up in thin layers. Researchers will check how well each method holds up over tim…

This study tests whether adding hyaluronic acid to a platelet-rich fibrin membrane improves the treatment of receding gums. Thirty adults with a specific type of gum recession will receive either the PRF membrane alone or with hyaluronic acid, alongside a surgical flap procedure.…

This study tests a drug called entrectinib in children with advanced solid tumors or brain tumors that have come back or haven't responded to other treatments. The trial has two parts: first finding the best dose, then seeing how well it works in children whose tumors have specif…

This trial tests a sticky patch that releases fenretinide, a vitamin A derivative, directly onto precancerous spots inside the mouth. The goal is to see if the patch can shrink these lesions, reduce their severity under the microscope, and lower genetic changes linked to oral can…

This phase II trial is testing whether combining the immunotherapy drug cemiplimab with low doses of two chemotherapy drugs (paclitaxel and carboplatin) can shrink tumors in people with head and neck cancer that has come back or spread. The study includes 46 participants who have…

This study tests whether a vitamin D-based gel (calcipotriol) or a light-activated treatment (photodynamic therapy) can shrink or eliminate oral leukoplakia, a precancerous condition. Thirty adults with mild to moderate dysplasia will receive one of the two treatments for four we…

This early-phase trial is testing whether adding the drug peposertib to standard radiation therapy is safe and effective for people with advanced head and neck cancer who cannot take the chemotherapy drug cisplatin. The study involves 21 participants and aims to find the best dos…

This phase 3 study tests whether ianalumab, a biologic drug, can reduce disease activity and symptoms in people with active Sjogren's syndrome. About 506 adults with a recent diagnosis (within 7.5 years) and positive anti-Ro/SSA antibodies are randomly assigned to receive ianalum…

This study tests a new device called SNIP designed to treat tongue-tie in infants. The device is used to perform a frenectomy, a procedure that releases the tight band under the tongue. The study includes 6 infants with anterior tongue-tie and focuses on how easy the device is fo…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This study tests a new dental filling made with coconut nanoparticles for children's baby teeth. Sixty children aged 5 to 9 with cavities will receive either the new coconut filling or a standard glass ionomer filling. Researchers will check the fillings' surface, shape, and how …

This early-phase trial tests whether injecting the cancer drug nivolumab directly into high-risk precancerous mouth lesions is safe and can shrink them. The study involves 18 adults with untreated oral lesions. The goal is to see if this local approach can reduce the risk of thes…

This study tests a three-drug combination (sorafenib, carboplatin, and paclitaxel) in 48 people with head and neck cancer that has spread or returned. The goal is to see how well the treatment shrinks tumors and delays cancer growth. Participants must have a confirmed diagnosis a…

This early-stage trial tests an experimental drug called AZD9592, alone or with other cancer drugs, in about 167 adults with advanced solid tumors (including lung, head & neck, and colorectal cancers). The main goals are to check safety, find the right dose, and see if the drug s…

This early-phase trial tests a new cell therapy called BEN301 for several autoimmune diseases, including scleroderma and rheumatoid arthritis. The therapy uses specially engineered immune cells (CAR-Treg cells) to calm the overactive immune system. The study involves 24 adults an…

This study tests a combination of two drugs—pemetrexed (chemotherapy) and pembrolizumab (immunotherapy)—in people with salivary gland cancer that has returned or spread. The goal is to see if this combo can shrink tumors or slow the disease. About 45 adults with advanced salivary…

This study tests if a new 2mL auto-injector or pre-filled syringe delivers the same amount of the drug ianalumab into the body as the current 1mL syringe. About 155 adults with rheumatoid arthritis, Sjögren's disease, or lupus will receive the drug both ways to compare how much g…

This study compares two types of dental crowns for baby molars in 100 children aged 3-7. Each child gets a zirconia crown on one molar and a stainless steel crown on the opposite molar. Researchers will check gum health, plaque buildup, and parent satisfaction over 3 years to see…

This trial tests whether adding a healing material made from the patient's own blood (Advanced Platelet-Rich Fibrin, or A-PRF) to standard gum surgery helps cover exposed tooth roots better than surgery alone. Eleven adults with gum recession will receive either the combined trea…

This study tests whether new plastic-like PEEK crowns work as well as standard metal crowns for children's back teeth after a common nerve treatment (pulpotomy). Sixty kids aged 5-9 got one PEEK crown and one metal crown on opposite sides of their mouth. Researchers checked gum h…

This study tests whether giving two immunotherapy drugs (tiragolumab and atezolizumab) before and after standard surgery and chemoradiation can help control advanced oral cancer. It includes 29 adults with newly diagnosed, stage 3-4 oral cavity squamous cell carcinoma that has a …

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This study planned to test a new cell therapy (CD19-BCMA CAR-T) for people with connective tissue diseases like lupus and rheumatoid arthritis. The goal was to see if it is safe and can control the disease. However, the study was withdrawn before enrolling any participants, so no…

This study looks at whether adding chemotherapy (cisplatin) to standard radiation therapy after surgery helps people with high-risk salivary gland tumors live longer without the cancer returning. About 252 adults whose tumors were removed took part. The goal is to see if the comb…

This study tests whether a toothpaste with stannous fluoride works better than regular fluoride toothpaste at reducing dental plaque and gum inflammation (gingivitis). About 85 adults with mild to moderate gum disease will brush twice daily for 6 months. Dentists will measure pla…

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This study tests four different ways to apply a new universal dental adhesive when fixing cavities on the side of teeth. Fifty patients will receive a total of 200 fillings, each using a different application method. The fillings will be checked every six months for four years to…

This trial tests four methods of activating the cleaning liquid during root canal treatment in adults aged 20 to 40 with an infected lower first molar. The goal is to see which method helps the infection at the root tip heal best after 12 months. Participants receive one-visit ro…

This study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…

This phase 2 trial tests whether amivantamab can shrink tumors or slow disease in 21 people with recurrent or metastatic adenoid cystic carcinoma, a rare salivary gland cancer. Participants receive weekly or biweekly infusions of the drug. The main goal is to see how many patient…

This study tests a shorter, more intense course of radiation therapy (hypofractionated IMRT) given after surgery for head and neck cancer. The goal is to see if it is safe and if it can help patients maintain better swallowing function compared to the standard longer radiation sc…

This study tests whether artificial intelligence (AI) can design dental crowns as well as a human technician. Forty adults with a damaged back tooth will receive either an AI-designed crown or a standard computer-designed one. Researchers will check for cracks, loosening, and ove…

This study tests whether personalized oral hygiene advice, delivered through an AI-powered mobile health app by trained volunteers, can improve gum health in older adults. Eighty-eight participants aged 60 and over from daycare centers in Hong Kong will receive bi-weekly advice b…

This study compares three types of bioactive dental fillings for cavities in back teeth. Fifty-five healthy adults aged 18 to 50 with at least three cavities will receive each filling type in different teeth. Researchers will check how well the fillings hold up, their appearance,…

This study tests a structured nutrition plan for 300 ICU patients who had abdominal surgery and cannot eat normally. The plan includes IV nutrition, oral supplements, and a device to measure calorie needs. Researchers will track infections, ICU stay length, and muscle loss to see…

This study aimed to compare two surgical techniques for covering exposed tooth roots caused by gum recession, using a porcine (pig) collagen matrix as a graft material. The trial planned to enroll 20 non-smoking adults with multiple gum recessions. However, the study was withdraw…

This study compares a new injectable tooth filling material to a conventional one for treating cavities in back teeth (molars). About 120 people with cavities will receive one of the two fillings. Researchers will check how well the fillings hold up over time, looking at color, c…

This phase 3 trial tests whether efgartigimod, given as a shot under the skin, can reduce disease activity in adults with moderate-to-severe primary Sjögren's disease. About 631 participants will receive either the drug or a placebo for 48 weeks, with an option to continue treatm…

This study tests whether applying 5-fluorouracil cream or Carnoy's solution after cyst removal lowers the chance of the cyst coming back. Fifty adults with odontogenic keratocysts in the jaw will be treated and followed for up to five years. The main goal is to see which method l…

This study tested two methods for preparing gum grafts to treat receding gums. One method uses a scalpel outside the mouth, the other uses a radiofrequency device inside the mouth. Forty-eight patients received one of these grafts along with a surgical gum lift. Researchers check…

This study compares two types of dental onlays (custom-made tooth covers) for treating decayed teeth. 164 adults will each receive one milled and one 3D-printed onlay to see which lasts longer over 10 years. The goal is to find out if the newer 3D-printing method is as good as th…

This study looks at two methods for placing glass ionomer fillings in the back baby teeth of 200 South African children aged 4-8. One method is done in a classroom using hand tools (ART), the other in a mobile clinic with standard equipment. Researchers will track how long the fi…

This study tests three different materials used to treat deep cavities in children's permanent molars that are still growing. The goal is to see which material best keeps the tooth alive and allows the root to finish forming normally. Sixty-nine children aged 7 to 10 will receive…

This study tests whether a mouthwash containing chlorhexidine and hyaluronic acid helps gums heal better after wisdom tooth removal. Fifty-four healthy adults who need wisdom tooth surgery will use the mouthwash, and doctors will check their healing over two weeks. The goal is to…

This study tests a modified pinhole surgical technique for treating localized gum recession. It compares using a bi-layer collagen membrane versus a connective tissue graft to cover exposed tooth roots. The trial involves 18 healthy adults with gum recession and will measure chan…

This study is testing a device called DaRT that delivers alpha radiation directly into tumors. It is for people with skin cancer, mouth tumors, or superficial soft tissue sarcoma who have not responded to other treatments or cannot have standard therapy. The goal is to see if the…

This study compares two ways of making dental onlays (custom tooth restorations) for damaged molars: milling from a solid block versus 3D printing. Thirty adults with cavities, broken teeth, or old fillings will receive either a milled or 3D-printed onlay. Researchers will check …

This study compares two types of dental cement used to place tooth-colored inlays (fillings) in cavities of back teeth. Fifty adults with large cavities or broken fillings will receive an inlay and be followed for 18 months to see which cement performs better in terms of strength…

This study tests whether giving targeted drugs based on the genetic makeup of a person's advanced salivary gland cancer can shrink tumors or stop them from growing. About 88 adults with cancer that has spread or come back are enrolled. Researchers are checking how well these trea…

This phase 3 trial tests deucravacitinib, an anti-inflammatory pill, in 774 adults with active Sjögren's syndrome. Participants receive either the drug or a placebo for 52 weeks. The goal is to see if the drug reduces disease activity and improves symptoms like dryness and fatigu…

This study tests a new high-strength ceramic material for dental crowns that can be made in a single appointment using a computer technique, avoiding the need for a temporary crown. 48 adults with a decayed, fractured, or poorly restored molar or premolar will receive the crown a…

This Phase 2 trial tests whether sibeprenlimab, a biologic drug given as a shot every 4 weeks, can reduce disease activity and symptoms in people with Sjögren's disease. About 83 adults with moderate-to-active disease will receive either the drug or a placebo, added to their usua…

This phase 2 trial is testing whether combining the immunotherapy drug pembrolizumab (Keytruda) with the chemotherapy drug docetaxel can shrink or control advanced thyroid and salivary gland cancers that are not responding to standard treatments. About 46 participants will receiv…

This study in Malawi tests whether chewing xylitol gum three times a day during pregnancy can improve gum health and change the bacteria in the mouth and vagina. Researchers will also check if it reduces pregnancy complications and affects babies' brain development. 80 pregnant w…

This study compares three different dental adhesives used to fill non-carious cervical lesions, which are tooth defects not caused by cavities. Thirty healthy adults aged 18-55 will receive restorations using one of the adhesives, and the team will check how well they hold up aft…

This study looks at two materials, ferric sulphate and putty MTA, used to treat deep cavities in children's baby teeth. The goal is to see which one works better and is safer than a traditional chemical. Sixty healthy children will be treated and followed for up to a year to chec…

This study looks at how well a new type of tooth-colored ceramic (3D shaded zirconia) works for making dental crowns, onlays, and bridges in a single dental visit using a computer design and milling machine. About 82 adults aged 18 to 75 who need a crown or onlay on a back tooth …

This study tests two treatments made from a child's own blood—concentrated growth factor (CGF) and platelet-rich fibrin (PRF)—to help regrow the roots of a damaged permanent molar. Sixty children with an immature, infected lower first molar will receive one of the two treatments …

This study tests whether a gel containing silver diamine fluoride can stop cavities in preschool children as effectively as the standard liquid version. About 630 healthy children with at least one cavity will receive the gel or solution every six months for 30 months. The goal i…

This study compares two different incision methods for gum graft surgery to treat receding gums. Twenty-two adults with gum recession and thin gum tissue will receive a graft made from donated skin. The goal is to see which method covers more exposed tooth root and causes less pa…

This study is testing a new type of dental implant with a special surface (EK III NH) in 30 adults aged 20-80 who are missing teeth. Participants receive the implant and a temporary tooth replacement right away. Researchers will track how well the implant works over two years usi…

This phase 2 trial tests a combination of two chemotherapy drugs (carboplatin and nab-paclitaxel) plus an immunotherapy drug (durvalumab) given before surgery for people with locally advanced head and neck cancer. The goal is to shrink or eliminate the tumor so that radiation—whi…

This study tests three non-drilling treatments—silver diamine fluoride, a self-assembling peptide, and fluoride varnish—to see if they can stop or reverse early cavities in children's baby teeth. About 90 kids aged 4-10 with early tooth decay will be randomly assigned to one of t…

This study looks at two ways to replace a missing lower molar with a dental implant. After the tooth is pulled and the bone heals for 12 weeks, some participants get a temporary crown right after implant surgery (immediate loading), while others wait 4 weeks before getting a temp…

This study tests enzalutamide, a drug already approved for other cancers, in 46 people with a specific type of salivary gland cancer that has androgen receptors. The goal is to see if the drug can shrink tumors by at least 30% in 1 out of 5 patients. Researchers will also track h…

This early-phase trial is testing a CAR-T cell therapy called RD06-04 in 12 people with active autoimmune diseases like lupus, scleroderma, and vasculitis. The treatment involves reprogramming a patient's own immune cells to target and destroy faulty B cells. The main goal is to …

This study tests whether motivational interviewing, a supportive counseling method, can help teenagers aged 14-19 with braces improve their oral hygiene. Participants receive short, non-judgmental conversations to set their own goals for brushing and flossing. The goal is to redu…

This early-phase trial planned to test a one-time infusion of genetically modified immune cells (CAR-T cells) targeting CD19 in people with several autoimmune diseases, including lupus and multiple sclerosis. The goal was to see if it was safe and could reduce harmful antibodies.…

This study tested whether adding injectable Platelet-Rich Fibrin (i-PRF), a natural concentrate from a patient's own blood, to standard deep cleaning improves gum disease outcomes. In 13 adults with moderate to severe periodontitis, one side of the mouth received the combined tre…

This study tests two immunotherapy drugs, nivolumab and ipilimumab, given before surgery to people with oral cavity squamous cell carcinoma. The goal is to see if these drugs can shrink tumors and are safe to use. About 30 adults with tumors larger than 2 cm or lymph node involve…

This study tests whether adding two drugs, pembrolizumab and olaparib, before and after standard chemoradiation can help control locally advanced head and neck cancer. About 45 adults with this cancer will receive the drug combination. The main goal is to see if this approach imp…

This study tests whether placing omega-3 fatty acids inside a damaged tooth can help it regrow root length and dentin, compared to the standard method of inducing bleeding. Twenty patients aged 6 to 28 with immature permanent teeth that have died due to injury or decay will be tr…

This study tests a special tooth-colored filling called alkasite composite (Cention Forte) for baby molars that have had pulp treatment. Twenty-five healthy children with deep cavities received this filling. Researchers are checking how well the fillings hold up over time using s…

This study tests two drugs, pembrolizumab and cabozantinib, in 36 people with head and neck cancer that has returned or spread and cannot be surgically removed. The goal is to see if the combination shrinks tumors and delays cancer growth. Participants receive both drugs intraven…

This study looks at three different ways to treat deep cavities in children's baby molars without pulling the tooth. The treatments are two types of pulpotomy (removing part of the tooth nerve and placing a material on it) and an indirect pulp cap (leaving some decay and sealing …

This study tests whether a new tooth-colored crown (Bioflx) works as well as the standard metal crown for fixing severely decayed baby molars in children aged 4 to 10. Each child gets one of each type on opposite sides of the mouth, and researchers check durability, gum health, a…

This study tests a new way to lift the sinus floor using a special drill (Densah bur) guided by a surgical template, while placing a dental implant at the same time. Ten patients with missing upper back teeth and a shallow sinus will receive this procedure. The goal is to see how…

This study compares three modern dental materials used to treat deep cavities in children's permanent molars by preserving the tooth nerve. The goal is to see which material best helps the tooth root continue growing and reduces pain. About 48 healthy children aged 7 to 11 with o…

This study tests whether using a diode laser before placing a special filling material (Biodentine) helps preserve more healthy tooth and reduces staining compared to using Biodentine alone. 48 adults with deep cavities in permanent back teeth are being treated and followed with …

This study tests an oral drug called APG-157 given before standard treatment (surgery or radiation) for people with newly diagnosed head and neck cancer. The goal is to see if the drug can shrink tumors and improve outcomes. About 24 adults with early to advanced stage cancer wil…

This study compares three dental procedures—pulpotomy, partial pulpotomy, and direct pulp capping—all using a material called MTA, to treat deep cavities in children's baby molars. The goal is to see which technique best preserves the tooth, prevents pain, and avoids infection. T…

This study tests three materials—amniotic membrane, mineral trioxide aggregate putty, and biodentine—for treating deep cavities in children's permanent molars that are still growing. The goal is to help the tooth root finish developing and avoid root canal or extraction. Seventy-…

This phase III trial studies whether adding the drug cetuximab to modern radiation therapy improves survival for people with advanced head and neck cancer that has been surgically removed. About 700 participants received either radiation alone or radiation plus cetuximab. The stu…

This study tests three types of dental fillings—high-viscosity glass ionomer, bulk-fill composite, and conventional composite—in 110 adults with deep cavities. The goal is to see which material performs best and causes less irritation to the tooth's nerve. Participants are health…

This study tests whether a newer version of a blood-derived filling (Advanced Platelet-Rich Fibrin) helps bone and gums heal better than the standard version after a tooth is pulled and a dental implant is placed right away. Sixteen healthy adults with a badly decayed back tooth …

This study compares a new self-cured bioactive filling material to a standard one for treating deep cavities in back teeth. Twenty-five patients with two decayed molars will receive one of each filling, then be monitored for up to two years. Researchers will measure how well the …

This early-phase trial is testing the safety of tofacitinib (Xeljanz), a drug already used for rheumatoid arthritis, in 23 adults with mild-to-moderate Sjogren's syndrome. Participants take the drug or a placebo daily for 168 days. The goal is to see if the drug is safe and toler…

This study tests whether microneedling, with or without a growth factor injection, can thicken the gum tissue around dental implants. Twenty people with thin gums will receive either the growth factor alone or microneedling plus the growth factor. The goal is to see if this simpl…

This study tests two different varnishes for treating white spot lesions, which are early signs of tooth decay common after braces. One varnish uses a self-assembling peptide to help rebuild enamel, while the other delivers calcium and phosphate. Thirty-eight people aged 15-25 wi…

This study compares a new bioactive filling material to a standard resin composite for treating cavities. 31 adults with at least two cavities will receive both types of fillings and be monitored for up to 4 years. The goal is to see which material performs better in terms of dur…

This phase 2 trial tests whether adding the immunotherapy drug tirellizumab plus chemotherapy before standard surgery can improve outcomes for people with early oral squamous cell carcinoma. Sixty participants will be randomly assigned to either the drug combo plus surgery or sur…

This study looks at whether a special light-activated dye can kill more bacteria and reduce pain after root canal treatment. Fifty adults with infected teeth will receive either standard care or the light therapy. The goal is to see if this simple addition improves healing and co…

This study tested four different types of tooth-colored fillings (flowable resin composites) to see which works best for fixing cavities. Twenty-eight adults each received at least four fillings, and the fillings were checked over two years. The goal was to find out if newer, sel…

This study compares three types of dental filling materials for repairing non-carious cervical lesions (tooth damage not caused by cavities). Thirty-three adults with at least three such lesions will receive each material in different teeth. Over two years, dentists will rate how…

This study compared two types of tooth fillings for cavities between teeth. 23 adults received either a glass ionomer or a bulk-fill composite resin filling. The fillings were checked at regular visits over 4 years to see how well they held up. The goal was to find out which mate…

This study tests two types of donated human tissue grafts for treating gum recession. Twenty adults who need a gum graft will receive either a standard graft or a new micro-surfaced version. Researchers will compare how well the gum covers the tooth root, how the site heals, and …

This study compares two materials—enamel matrix derivative and amniotic membrane—to standard blood-clot therapy for regenerating roots of non-vital immature permanent front teeth in children aged 7 to 12. The goal is to see which approach best promotes root growth, closes the ope…

This study looks at how well tooth-colored fillings hold up in baby molars that have had a pulpotomy (a procedure to remove infected pulp) compared to similar fillings in teeth without pulpotomy. About 40 healthy children aged 3-9 will be followed for 24 months. The goal is to se…

This study compares two methods of preparing the jawbone for dental implants: a newer technique called osseodensification and the conventional method. The goal is to see which provides better initial stability for the implant, which is important for long-term success. The study i…

This study tests three different dental cements used to attach prefabricated zirconia crowns to children's front baby teeth. Thirty-six children with cavities will receive crowns, and researchers will check crown retention, gum health, plaque buildup, and parent satisfaction at 1…

This study tests a collagen-based bone graft material (Bio-Oss Collagen) for sinus augmentation in people with bone loss and missing teeth. The goal is to see if it helps grow enough bone to support a dental implant. The study involves 36 adults who need a single implant in the u…

This study compares two types of tooth-colored fillings for cavities on the chewing surface of back teeth. One is a new injectable resin composite, and the other is a conventional composite. Over 24 months, researchers will check how well each filling stays in place, resists stai…

This study compares two types of tooth-colored filling materials for cavities between teeth. 54 healthy adults aged 18-60 received fillings using either a standard bulk-fill composite or a newer thermoviscous material. Researchers will check the fillings at 6 and 12 months for ho…

This study compares two materials used to make dental onlays (a type of tooth filling for molars): a high-performance polymer called BioHPP and a ceramic called lithium disilicate. Forty participants received onlays made from one of these materials. Researchers will evaluate how …

This study tests two new dental filling materials for cavities in back teeth. 65 adults with cavities or old fillings that need replacing will receive the new fillings and be checked for pain, function, and appearance over 5 years. The goal is to see if the materials are safe and…

This study tests a new dual-cure adhesive used to bond ceramic inlays and onlays to teeth. Researchers will check how often patients have tooth sensitivity after the procedure and how well the restoration holds up over time. 45 adults aged 18-65 with cavities in molars or premola…

This study aimed to compare different surgical techniques for treating receding gums, including a flap procedure and a tunnel approach, with or without a platelet concentrate. It was designed for 100 adults with multiple gum recessions. However, the trial was withdrawn before enr…

This study tests whether two drugs, lenvatinib and pembrolizumab, can shrink or slow the growth of advanced salivary gland cancers, including adenoid cystic carcinoma, that have come back or spread. About 64 participants will receive the combination therapy. The goal is to see ho…

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) combined with radiation works better than the standard chemotherapy drug cisplatin with radiation for patients with a certain type of head and neck cancer (p16-positive). About 126 adults with advanced or in…

This study tested two surgical techniques to fix receding gums on the lower front teeth. 26 adults with gum recession received either a modified laterally stretched technique or a tunneling method with a connective tissue graft. The goal was to see which approach better covers ex…

This study tests whether a new nano-based paste (chitosan-coated silver nanoparticles) works better than a standard antibiotic paste for treating infected baby molars in children aged 4-8. The goal is to reduce pain, swelling, and infection, and to see which paste kills bacteria …

This study compares three different dental adhesives used to repair non-carious cervical lesions (tooth damage not caused by cavities). Eighteen adults with at least three such lesions will receive restorations using a flowable composite resin. The goal is to see which adhesive p…

This study is checking how safe and effective a new membrane made from pig tissue is for dental surgery. It involves 50 adults who need gum tissue regeneration around teeth or implants. Researchers will monitor for complications and measure gum thickness and width over 24 months.

This phase 2 trial tests the immunotherapy drug pembrolizumab (Keytruda) in people with 15 types of advanced solid tumors that have worsened after standard treatments. About 1,600 participants receive the drug to see if their tumors shrink or stop growing. The study also looks fo…

This study tests whether brushing with stannous fluoride toothpaste twice a day for three months reduces gum bleeding and inflammation better than a standard fluoride toothpaste. 120 adults with mild to moderate gingivitis will be randomly assigned to one of three toothpastes. Th…

This study compares using cyclosporine eye drops alone versus combining them with absorbable punctal plugs for dry eye caused by Sjögren's syndrome. Thirty participants will receive the drops in both eyes and a plug in one eye to see if the combination improves symptoms better. T…

This study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…

This study tests a fluorescent dye called PARPi-FL that may make oral cancer cells glow during an endoscopic exam. About 23 people with oral squamous cell carcinoma will gargle the dye before surgery, and doctors will check for safety and how well the dye highlights tumors. It is…

This trial tests whether an artificial intelligence model can accurately diagnose gingivitis — early gum disease — by analyzing digital photographs and X-rays. Researchers will compare the AI's assessments to those of dental experts. If it works, this approach could make gum dise…

This phase 1 trial is testing a new imaging tracer called 68Ga-FAPI-46 to see where it collects in normal and cancerous tissues. About 30 people with various solid tumors or blood cancers will receive the tracer and then undergo a PET/CT scan. The goal is to understand how the tr…

This study is testing whether artificial intelligence (AI) can accurately diagnose periodontitis (severe gum disease) and monitor gum inflammation using dental records and X-rays. Researchers will develop and validate AI models using data from 900 patients across multiple hospita…

This study tests a new dye, called cRGDY-PEG-Cy5.5-C dots, to help surgeons see cancer in lymph nodes during head and neck melanoma surgery. About 67 people will receive the dye injection around their tumor before or during surgery. The dye is not a treatment, but may improve how…

This study tests whether special imaging devices can better detect pre-cancerous or cancerous spots in the mouth compared to a standard visual exam. About 63 adults with suspicious mouth lesions or a history of oral cancer will be followed over time. The goal is to see if these a…

This study tests a blue dye called BlueCheck to see if it can find early tooth decay and track whether the decay is healing. Twelve adults will wear a special denture with pieces of human tooth enamel for 28 days. The dye's results are compared to standard dental tools to see if …

Researchers are testing three mouthwashes, licorice, clove, and chlorhexidine, in Egyptian children aged 7 to 12 who have a high risk of cavities. The trial measures levels of Streptococcus mutans, a bacterium linked to tooth decay, in saliva before and after children use their a…

Researchers are testing whether fluoridated bottled water prevents tooth decay in young children. The trial enrolls 200 children starting at 2 to 6 months of age and follows them until around their fourth birthday. Families receive either fluoridated or non-fluoridated bottled wa…

Researchers at Trinity College Dublin are testing whether adding an adhesive bonding step before placing fissure sealants helps the sealants stay on children's permanent molars and prevents cavities. The trial includes 100 children aged 6 to 12 who are at high risk of tooth decay…

Removing an impacted lower wisdom tooth can leave a painful complication called dry socket, where the protective blood clot in the empty socket breaks down. This trial compares two liquids used to rinse the socket right after extraction: normal saline and chlorhexidine, an antise…

This study tests whether metformin, a common diabetes drug, can prevent oral cancer in people with precancerous white or red patches in the mouth. About 34 participants will receive either metformin or a placebo for several months. Researchers will check if the patches shrink or …

This study tests whether specially designed videos can help parents of young children prevent early childhood cavities. The program uses motivational messages to encourage good oral health habits. Researchers are following over 1,200 families enrolled in the WIC program in Iowa, …

This trial tests whether a bioactive resin containing S-PRG filler, used as attachment material for clear orthodontic aligners, can prevent white spot lesions (early decay) on tooth enamel. Fifty healthy young adults with mild to moderate crowding will be randomly assigned to rec…

This study tests whether a topical 10% povidone-iodine solution can prevent white spot lesions on the front teeth of teens undergoing fixed orthodontic treatment. Healthy participants aged 10 to 17 will receive either the iodine solution or a placebo applied to all tooth surfaces…

This study investigates whether a painless fluorescent light exam can help find early warning signs of oral cancer in adults. Participants complete a health questionnaire and receive a standard oral exam plus a fluorescence scan. The goal is to see if this simple, non-invasive to…

This phase 2 trial tests whether metformin, a widely used diabetes drug, can prevent oral cancer in 26 people with precancerous mouth lesions (leukoplakia or erythroplakia). Participants take metformin by mouth, and researchers check if the lesions shrink or disappear. The goal i…

This study tests whether using home sensors to monitor dehydration risk can reduce hospitalizations and emergency room visits in head and neck cancer patients. About 427 participants will either use the CYCORE sensor system plus standard care, or standard care alone. The goal is …

This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a s…

This study tests whether adding a special glass material to standard fluoride varnish can better prevent root cavities in adults over 60. Researchers will compare the two varnishes in 540 older adults over 36 months. The goal is to see which one reduces new cavities and helps sto…

This study tests two different dental sealants—a resin-based and a glass ionomer-based—on partially erupted permanent molars in children aged 10-15. The goal is to see which one lasts longer and prevents cavities better over one year. Forty healthy children will each get both typ…

This study tests simple educational programs for parents of children aged 9 months to 3 years. The goal is to see if these brief lessons can help prevent cavities and reduce behavior problems. Researchers will track dental records and behavior outcomes for 750 children.

This study tests a silver diamine fluoride (SDF) gel to prevent cavities in 1,500 healthy preschool children. The gel is applied every six months for two years and compared to standard fluoride varnish. The goal is to see if the SDF gel better protects teeth from decay.

This study tests whether using a fluoride-releasing composite resin for aligner attachments can prevent white spot lesions (early cavities) during clear aligner therapy. Twenty-four people aged 16-24 with mild crowding will have one side of their mouth get the fluoride resin and …

This study tests a program for children in Colombia that combines water filters with educational sessions for parents and kids to reduce high fluoride exposure. About 90 children from kindergartens will take part, with half getting the full program and the other half receiving st…

This study tests a program to reduce high fluoride exposure in children living in Huila, Colombia. The program includes installing water filters at kindergartens and teaching parents and kids about healthy habits. Researchers will measure fluoride levels in children's urine and p…

This study tests whether a special mouthwash containing N-acetylcysteine can prevent painful mouth sores (oral mucositis) in patients receiving a stem cell transplant. These sores are a common and serious side effect that can cause severe pain and longer hospital stays. The trial…

This study tests whether applying fluoride varnish to teeth can prevent white spot lesions in people undergoing clear aligner treatment. Twenty-five participants aged 16 to 24 with mild crowding will have one side of their mouth treated with fluoride varnish and the other side le…

This study tests if shining a special light inside the mouth, outside the cheek, or both can prevent severe mouth sores in people getting a stem cell transplant. About 78 patients will receive daily light therapy during their transplant stay. The goal is to find the best way to r…

This study tests a special tooth sealant that works even on wet teeth. Researchers will apply the sealant to 500 molars in 250 children aged 7-11, comparing how well it holds up when the tooth is dried for 3 seconds versus 15 seconds. The goal is to see if the sealant prevents ca…

This study aimed to see if chewing xylitol gum could prevent cavities in children aged 5 to 14 living in Ladakh, India. Participants would have chewed gum with either 100% or 22% xylitol daily for a school year. However, the study was withdrawn before any children enrolled, so no…

This study tests whether teaching children in Uganda how to brush their teeth, use fluoride varnish, and eat healthy foods can prevent cavities. About 610 school children aged 5-17 will be split into two groups: one gets the prevention program, the other does not. Researchers wil…

This study tests three approaches to prevent cavities in 180 children aged 6-7 in Karachi, Pakistan. One group brushes with fluoride toothpaste, another adds dietary advice, and the third also gets sealants on their back teeth. The goal is to find the most effective and affordabl…

Researchers at Hanoi Medical University are studying whether small lingual appliances can correct an excessive Curve of Wilson at the lower second molars in people already wearing labial fixed braces. The trial uses a split-mouth design: one side of the mouth receives the auxilia…

Researchers are testing whether a low-level laser therapy device called Luminance RED can reduce pain and discomfort from recurrent canker sores. Adults who get canker sores at least once a month use the device at home and report daily pain and how hard it is to eat, drink, and b…

Researchers compare two materials for the framework that supports a full set of replacement teeth on four dental implants in the lower jaw. Ten completely edentulous patients receive either a titanium or a nano-carbon fiber-reinforced CAD/CAM framework. The study tracks gum healt…

This trial compares two final rinses used during two-visit root canal treatment for adults with symptomatic irreversible pulpitis, a painful tooth infection. Participants receive either a dexamethasone solution or normal saline as the last rinse inside the root canal. Researchers…

Researchers compare two medicines placed inside root canals during a two-visit root canal treatment for infected mandibular molars. One medicine is Hyalone, a hyaluronic acid gel, and the other is calcium hydroxide, a standard disinfectant paste. The trial enrolls 24 adults with …

Researchers are testing a new medical device called Bocaliner in people who have painful mouth sores caused by chemotherapy or radiation. The device is held in the mouth after using medicated mouthwashes, gels, or rinses, with the goal of keeping those treatments in contact with …

This study tested two ways to teach people with gingivitis (early gum disease) how to clean their teeth better. One group watched a video, the other practiced on a dental model. After one month, both groups showed improved gum health and awareness, with no major difference betwee…

This trial tests whether two dental cements, MTA and CIMMO DTA®, differ in reducing pain after a pulpotomy—a procedure that removes the inflamed pulp inside a tooth—in children aged 6 to 16 with molar-incisor hypomineralization (MIH), deep decay, and irreversible pulpitis. Partic…

This trial tests whether using sodium hypochlorite as a gel or solution, with or without tiny nanoparticles, affects pain after a pulpotomy—a procedure that removes the inflamed pulp inside a tooth. Adults aged 15 to 40 with severe pulpitis in a lower molar will be randomly assig…

This trial tests whether applying cryotherapy (cold therapy) along with different concentrations of sodium hypochlorite irrigation during vital pulp therapy can reduce post-operative pain in permanent mandibular molars. Adults aged 15-40 with symptomatic irreversible pulpitis wil…

This study looks at whether a toothpaste with a special ingredient (calcium sodium phosphosilicate) can improve daily life for people with sensitive teeth. About 500 adults aged 18 to 65 with self-reported tooth sensitivity will use the toothpaste for 24 weeks. Researchers will m…

This study tests whether a nerve block placed in the face can reduce pain and the need for strong opioid drugs after cleft palate surgery in children. The goal is to help kids start eating and drinking sooner and go home faster. The study involves 40 children having cleft palate …

This trial tests Gelclair, a mouth rinse that forms a protective coating over the mouth's lining, to see if it eases the painful mouth sores (oral mucositis) caused by radiation therapy for head and neck cancer. The study enrolls adults with squamous cell carcinoma who will recei…

This trial tests whether a special remineralizing gum can improve oral health in adults who have bad breath, sensitive teeth, or gum discomfort. Participants chew one piece of gum daily for 30 days and report changes in breath freshness, tooth sensitivity, and gum comfort. The st…

This study tests two ways to activate a bleaching gel on teeth: using a laser or an LED light. Researchers want to see which method whitens better, causes less tooth sensitivity, and leaves teeth smoother. 45 adults aged 20-35 who want whiter teeth will take part in this single-s…

This phase 2 trial tests whether the drug RRx-001 can prevent severe oral mucositis (painful mouth sores) in 216 patients with head and neck cancer receiving standard chemoradiation. Patients are randomly assigned to receive RRx-001 or a placebo alongside their usual treatment. T…

This study tests whether using a portable light device (photobiomodulation) at home for 8 minutes daily can reduce pain, root damage, and improve gum health in adults getting braces. Fifty patients aged 18–35 who need premolar extractions will use the device alongside standard br…

This study tests whether using cold or laser-activated fluids during a root canal can reduce pain and kill more bacteria than standard treatment. Sixty adults with an infected lower molar will receive one of four rinses: room-temperature, cold, heated, or laser-activated sodium h…

This study compares four different rinsing tools used after root canal treatment to see which one reduces pain the most. Fifty-two adults with an infected lower back tooth will be randomly assigned to one of four groups. They will rate their pain at several times over two days an…

This study compares two pain management strategies for adults with oral cancer who have moderate to severe pain. One group receives the opioid tramadol, while the other gets a combination of pregabalin and naproxen sodium. Over 7 days, researchers measure pain reduction, side eff…

This small pilot study tests two different stitching techniques during gum surgery to cover exposed tooth roots caused by gum recession. Seven healthy adults with multiple areas of gum recession will receive both techniques in different parts of their mouth. The goal is to see wh…

This study compares a new, minimally invasive keyhole surgery (endoscopic parotidectomy) to the standard open surgery for removing benign (non-cancerous) tumors from the parotid gland, a major salivary gland. The goal is to see if the keyhole approach is as safe and effective, wi…

This study tested two different ways of applying a whitening gel to see which causes less tooth sensitivity. Forty adults with darker teeth received two bleaching sessions one week apart. One group had the gel applied for 40 minutes straight, the other for two 20-minute sessions.…

This study tests different ways of applying a dental adhesive and filling material to see which method keeps fillings intact and stain-free for up to 5 years. Fifty adults with cavities or old fillings needing replacement will receive four different filling types. The goal is to …

This study tests whether taking vitamin D3 before a root canal can reduce pain afterward. Fifty-four adults with low vitamin D and painful tooth inflammation will receive either a single high dose, a three-day course, or a placebo. Pain levels and painkiller use will be tracked f…

This study compares two ways to restore a full upper jaw with dental implants: placing the permanent teeth right away versus waiting 6 weeks. Researchers want to see which timing leads to better implant stability and patient satisfaction. 24 adults with healed upper jaw tooth los…

This study tests a numbing method called intraseptal anesthesia for gum surgery. Sixty adults with gum disease will receive a small amount of articaine to see if it effectively blocks pain during the procedure. The goal is to find a less painful alternative to standard numbing te…

This early-phase study tests whether a mouthwash made from copaiba, a natural oil from the Amazon, can safely help prevent and treat painful mouth sores caused by radiation therapy in 20 adults with head and neck cancer. Researchers will find the highest safe dose and measure pai…

This study tested whether an ozone oil-based gel can reduce pain and prevent dry socket after lower wisdom tooth removal, compared to a standard CHX gel. One hundred patients received both treatments in separate sessions. Pain levels and dry socket occurrence were recorded for 48…

This study tests whether adding low-level laser therapy and vitamin D3 supplements to standard braces can help move teeth faster and reduce pain. Fifty adults with crowded lower front teeth will be split into groups: braces alone, braces plus vitamin D, or braces plus both laser …

This study compares two treatments for severe tooth pain: vital pulp therapy, which tries to save the tooth's nerve, and standard root canal treatment, which removes it. Researchers will measure pain after 24 hours and one week, and check healing at 6 and 12 months using AI to re…

This study tested how well different home oral hygiene devices (like interdental brushes and picks) reduce plaque and gum bleeding in 40 adults with gingivitis. Participants used the tools at home and were checked monthly. The goal was to see which device works best for everyday …

This study planned to test a mouthwash made from copaíba oil, a natural resin, to prevent and treat painful mouth sores (oral mucositis) in people with oral cancer undergoing radiation. The trial was set to include 40 patients, half using the copaíba mouthwash and half a placebo,…

This study tests whether a spray made from spirulina (a type of algae) can prevent or reduce severe mouth sores in people receiving radiation for head and neck cancer. About 70 patients will use either the spirulina spray or a placebo spray during their radiotherapy. The goal is …

This study looks at two ways to clean root canals (rotary vs. reciprocating files) and whether rinsing with very cold saline (cryotherapy) reduces pain after the procedure. Sixty adults with infected but painless teeth will be randomly assigned to one of four groups. Patients wil…

This study tests whether a remote rehabilitation app can improve shoulder and neck recovery in oral cancer patients who had neck dissection surgery. 80 patients are randomly assigned to either standard home exercise materials or the app, which provides daily reminders and lets pa…

This study looks at whether sonic electric toothbrushes or manual toothbrushes are better at reducing gum inflammation in pregnant women. Gum problems are common during pregnancy due to hormone changes. The trial will follow 120 pregnant women aged 18-40 to see which toothbrush t…

This study tests two ways to clean a tooth during a root canal: laser-activated irrigation and passive ultrasonic irrigation. Researchers want to see which method leads to less pain and better quality of life afterward. 90 adults with infected or damaged permanent teeth are takin…

This study tested whether laser therapy, a remineralizing paste called Remin Pro, or both together can reduce pain from sensitive teeth. Twenty-five adults with at least four sensitive teeth received one of the treatments and reported their pain levels over 12 months. The goal wa…

This study looks at pain after root canal treatment in adults with a tooth condition called irreversible pulpitis. Researchers are testing three different sealers (materials used to fill the root canal) to see which one leads to the least pain and need for painkillers. 75 partici…

This real-world study follows 33,000 cancer patients in France using the CareMin650™ device, which shines light on mouth sores and skin burns caused by chemotherapy or radiation. The goal is to see if this light therapy reduces the severity of these painful side effects. Research…

This study tests two treatments for burning mouth syndrome, a condition causing ongoing mouth pain without visible cause. One treatment uses low-level laser therapy (light energy), and the other uses a supplement called alpha-lipoic acid. Sixty adults with the condition will rece…

This study looks at whether applying cold therapy (cryotherapy) during a pulpotomy—a procedure to save a decayed tooth—can lower pain and improve quality of life afterward. About 82 adults with severe tooth pain will be treated, and their pain levels and daily comfort will be tra…

This study tests whether the antiviral drug valacyclovir can prevent or reduce painful mouth sores (oral mucositis) in adults receiving radiotherapy for head and neck cancer. Researchers will give either valacyclovir or a placebo to 84 participants during their radiation treatmen…

This study looks at whether a hands-on, simulation-based training program helps people with a new stoma feel more confident and capable in caring for it. About 70 adults who have a stoma for the first time will either receive standard education or the simulation-based training. R…

This study tests whether adding tiny antibacterial particles called mesoporous silica nanoparticles to standard root canal medication can reduce pain and kill more bacteria. Forty-two adults with infected lower molar teeth will receive one of three treatments: standard medication…

This study tests an experimental drug called dazodalibep in 434 adults with moderate-to-severe Sjögren's syndrome, an autoimmune disease causing dryness, fatigue, and pain. Participants receive either the drug or a placebo to see if it improves symptoms like dry eyes and mouth. T…

This study looks at tongue-tie in newborns and whether treating it helps with breastfeeding. Researchers will follow 300 infants for up to 5 years, comparing different treatments. The goal is to make breastfeeding easier and less painful for mothers.

This study tests whether a personalized digital coaching app, used with an electric toothbrush, helps adults brush twice daily for two minutes. 230 participants from California dental clinics will use the app for 19 weeks, receiving tailored feedback and reminders. The goal is to…

This study tests whether a 10% carbamide peroxide gel, used at home, can make white spot lesions on teeth less noticeable. About 67 adults with white spots on their front teeth will use the gel and report their satisfaction. The researchers will also check for side effects like t…

This study looks at different ways to clean a tooth during a root canal to see which causes the least pain and improves quality of life. 90 adults with a specific type of tooth infection will be randomly assigned to one of three irrigation methods. They will report their pain lev…

This study tests whether a single injection of dexamethasone (a steroid) near the tooth can reduce pain after root canal treatment for people with severe, irreversible tooth inflammation. 44 adults with this condition will receive either the steroid or a placebo (salt water) inje…

This study looks at whether applying a hyaluronic acid gel (Gingigel) and using a special light therapy (photobiomodulation) can help gums heal better and with less pain after a common gum surgery called gingivectomy. About 38 adults with enlarged gums will be split into three gr…

This study compares proton beam radiation to standard photon radiation (IMRT) for people with head and neck cancer. The goal is to see if proton therapy causes fewer side effects, like painful mouth sores, by exposing less healthy tissue to radiation. About 108 adults with certai…

This study tests two medications—Chlorhexidine gel and Nitrofurantoin paste—placed inside the tooth during root canal treatment to see which one reduces pain between visits better. 220 patients with infected teeth will report their pain levels before treatment and again after 24 …

This study looks at whether using cold, hot, or ultrasound-activated rinsing solutions can lower pain and bacteria after a root canal. Sixty adults with painful tooth pulp inflammation will receive one of four rinsing methods. The goal is to find which approach works best for a m…

This study tests whether a virtual reality (VR) game can lower anxiety and pain in children aged 6 to 10 during their first dental treatment. Half of the 88 kids will wear VR glasses showing an interactive game that explains each step, while the other half gets the standard 'tell…

This study compares two types of dental cement used to attach crowns and bridges: a newer resin-modified glass ionomer cement and a conventional glass ionomer cement. The goal is to see which one causes less tooth sensitivity after the procedure. About 496 people aged 15 to 70 wi…

Researchers at the University of Alberta are following 500 children who had a tongue-tie release as infants to see how often they later develop feeding, speech, dental, or sleep and breathing problems that need further evaluation. Tongue tie is a shortened band under the tongue t…

This study talks to people living with HIV from diverse backgrounds to learn what helps or hinders them from getting oral health care and cancer prevention. Researchers will hold focus groups and use questionnaires to understand barriers and gather ideas for improvement. The goal…

This study examines whether women with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth, also experience muscle loss, a condition called sarcopenia. Researchers will measure muscle strength, muscle mass, and physical performance in 120 participants…

This study follows over 8,600 women in Costa Rica who received the HPV vaccine (types 16 and 18) years ago, plus unvaccinated controls, to see how well the vaccine protects over time. Researchers are checking for cervical lesions, immune markers, and any increase in infections fr…

This observational study measures three proteins, PTHrP, RANKL, and OPG, in the fluid that seeps from the gums. Researchers will compare levels in 81 adults split into three groups: healthy gums, gingivitis, and periodontitis. During a routine dental exam, they collect fluid samp…

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This study aims to better understand fatigue by comparing people who have felt tired for more than a month with those who are not fatigued. Researchers will use questionnaires, physical tests, and optional brain scans to identify different types of fatigue. The goal is to gather …

This study investigates whether head and neck cancers caused by HPV have different genetic profiles compared to those linked to alcohol and tobacco use. By analyzing tumor biopsies, researchers aim to identify genetic markers that could predict how well a patient responds to chem…

This study looks at whether heart rate variability (small changes in heartbeat timing) and early signs of inflammation can help predict breathing or heart problems in children having their tonsils or adenoids removed. Researchers will monitor heart rhythms and measure immune mark…

This study looks at whether a rare tooth condition called taurodontism, where teeth have enlarged pulp chambers, is linked to gum disease. Researchers will review dental records and X-rays from healthy adults to compare gum health between those with and without taurodontism. The …

This study will look at 3D dental scans from 4,000 people to count how many roots each permanent tooth has. Researchers want to see if the number of roots differs between men and women, and how it changes with age. The goal is to better understand normal tooth anatomy, not to tes…

This study explores whether a health app and follow-up digital meetings can motivate teenagers to improve their oral hygiene. Researchers will interview 25 adolescents aged 16-17 who have gum disease (gingivitis) to see if the app helps them build better brushing habits. The goal…

This study compares three types of dental onlays (a type of filling that covers part of a tooth) for treating cavities. It involves 36 adults who each need at least three onlays. The onlays are made using 3D printing, milling, or indirect resin composite. Researchers will check h…

This study looks at how well different types of dentures and implant-supported dental devices help people chew and how they affect quality of life. Researchers will compare conventional dentures, mini-implant overdentures, and implant-assisted partial dentures in 240 adults. The …

This study looks at whether a special home care program helps people with a new stoma (a surgical opening on the belly) recover better after colorectal cancer surgery. About 98 adults who had a stoma created will get extra support and teaching to manage their stoma at home. The g…

This study follows 110 adults with lichen planus who are using topical steroids, the standard first treatment. Researchers will collect clinical details, saliva, blood, and tissue samples to identify factors linked to poor response. The goal is to understand why some patients don…

This study tests whether AI-generated messages can change how cancer survivors think about alcohol and cancer risk. About 850 adults who have had certain cancers and currently drink alcohol will view different messages. Researchers will measure changes in their beliefs about canc…

This study looks at whether artificial intelligence can help dentists plan where to place dental implants in people who have lost all their lower teeth. Researchers will use old CT scans to compare AI-generated implant plans with plans made by expert dentists. The goal is to see …

This study looks at how the size of root canal preparation and the amount of remaining tooth structure affect the survival of treated lower molars. Sixty patients with infected pulp will receive either a conventional or conservative root canal preparation. Researchers will track …

This study surveys general dentists in two UK regions to understand their knowledge and use of silver diamine fluoride (SDF), a liquid that stops tooth decay without drilling or needles. Researchers aim to identify barriers like training gaps or cost that prevent wider use in chi…

This study looks at immune system markers in the saliva and blood of 80 people with primary Sjögren's syndrome, a chronic disease causing dry eyes and mouth. Researchers will check for antibodies that may block a key enzyme and see how gum disease affects symptoms. The goal is to…

This study checks how many teeth remain functional 10 years after root canal treatment using a sealer called Endomethasone N. Researchers will review records from 179 adults who had the treatment at least 5 years ago. The goal is to understand the long-term success and safety of …

This study looks at how smoking changes the body's immune response in gum disease. Researchers compared smokers and non-smokers with healthy gums, gingivitis, or periodontitis. They measured specific proteins and genes in gum tissue to understand the link between smoking and infl…

This study compares two methods for measuring root canal length during root canal treatment: a manual technique using hand instruments and a machine-assisted mechanical technique. Both methods use electronic devices called apex locators to improve accuracy. About 104 adults needi…

This study looks at two common treatments for cavities in children's baby molars: ferric sulfate and sodium hypochlorite. Researchers will check how well each treatment worked by examining kids aged 4-9 during routine dental visits over 2 years. The goal is to see which agent lea…

This study looks at how two ways of cleaning cavities—removing all decayed tissue versus leaving some softer tissue near the nerve—change the types of bacteria left in the tooth. Researchers will take samples from 48 adults with cavities and analyze the DNA of the bacteria. The g…

This study looks at whether changing clear aligners every 7 days or every 14 days affects tooth root shortening and pain. Fifty-two adults with mild to moderate crowding are randomly assigned to one of two wear schedules. Researchers measure root length from X-rays taken before a…

This study follows 348 infants from birth to age 4 to see how tongue-tie (a tight piece of skin under the tongue) affects breastfeeding, feeding, and speech. Researchers will measure tongue movement and compare different ways to diagnose the condition. The goal is to provide clea…

This study reviewed 31 earlier studies to better understand how common impacted canine teeth are, where they get stuck, what causes it, and how to diagnose it. The review found that upper canine impaction affects about 1% to 7% of people, often toward the roof of the mouth. Commo…

White spot lesions are a common cosmetic problem during orthodontic treatment. This study tests whether placing the small composite attachments on the tongue side of clear aligners, instead of the front, reduces these spots. Fifty-two young adults with mild to moderate crowding a…

This study was designed to track pregnancies in women with rare autoimmune and systemic diseases to understand complications and improve care. It planned to enroll women with conditions like lupus, rheumatoid arthritis, and scleroderma. However, the study was withdrawn before any…

This study follows 200 premature babies who had a serious gut infection called necrotizing enterocolitis (NEC) to see how it affects their nutrition and growth by age 5. Researchers will check for problems like food allergies, poor growth, feeding difficulties, and other digestiv…

This pilot study is looking at whether dental erosion (loss of tooth enamel) could be a non-invasive biomarker for esophagogastric cancer and other cancers. Researchers will survey 174 participants (cancer patients and healthy volunteers) about diet, habits, and GERD symptoms, an…

This study tests whether 3D-printed, custom-made titanium plates help surgeons rebuild the jaw more accurately and quickly than standard plates. About 92 adults with jaw tumors, deformities, or other conditions will be randomly assigned to receive either type of plate during surg…

This study measures how hot the inside of a tooth gets when dentists shave off a tiny bit of enamel (a common step before braces). Researchers will test two different tools on 40 teeth from 30 people to see which method causes less heat. Keeping the tooth cool is important becaus…

This study follows 100 head and neck cancer patients receiving standard radiotherapy to see how their teeth, gums, and saliva change over time. Researchers measure gum health, tooth condition, and quality of life before and after treatment. The goal is to better understand these …

This study compares four different dental filling materials in 20 patients with cavities in their back teeth. The fillings are evaluated over 9 months for how well they hold up, look, and affect tooth health. The goal is to see if newer bioactive materials perform better than sta…

This study looks at how metal and ceramic braces change the bacteria in dental plaque (biofilm) and affect gum health in 80 people with crooked teeth. Researchers will measure the types and amounts of bacteria, plaque buildup, and gum swelling. The goal is to understand how diffe…

This study tests four different methods for removing the surface layer of gum tissue during dental grafting surgery. The methods include a surgical blade, a special drill (mucotome), a diamond bur, and a laser. Researchers will measure how much tissue remains, how long the proced…

This study looks at whether using augmented reality (AR) can improve how nurses learn to care for oral mucositis, a painful mouth condition caused by cancer treatments. About 110 nurses from a hospital in Taiwan will take part. Researchers will measure their knowledge, skills, an…

This study looks at whether testing the surgical wound for leftover tumor DNA can help predict if oral cancer will come back. Researchers will check for this DNA in 31 patients after their tumor is removed. The goal is to see if this test gives useful information beyond standard …

This study compares two methods of making 3D-printed dentures: scanning directly inside the mouth versus scanning a traditional mold. Eight people with no teeth will try both types of dentures to see which one stays in place better. The goal is to find out if the newer, more comf…

This trial tests three common ways to move the gums aside (gingival displacement) when taking impressions for dental crowns. 39 adults needing a single front tooth crown will receive one of three methods: a retraction cord, a retraction paste, or a cord plus hemostatic gel. Resea…

This study follows 80 adults who received dental restorations made with CAD/CAM digital technology to treat tooth wear. Researchers will check how well these restorations hold up over 5 years, looking at factors like breakage, wear, and patient satisfaction. The goal is to see if…

This study looks at two different types of lower dentures held in place by dental implants in adults aged 60-70. The goal is to see which design distributes bite force more evenly and stays more securely in the mouth. Researchers will use special devices to measure bite balance a…

This study looks at whether changes in gut bacteria can affect Sjögren's syndrome, an autoimmune disease causing dry eyes, dry mouth, and fatigue. Researchers will measure blood markers of gut leakage in 50 adults with Sjögren's to see if these markers change when disease activit…

This study looks at whether a person's genetic makeup influences how well a dental treatment called vital pulp therapy works for saving teeth with pulpitis (tooth nerve inflammation). Researchers will collect saliva from 96 participants to analyze specific genes, then track treat…

This study compares different types of dental tools (matrix systems) used to rebuild the shape of a tooth when filling large cavities. Ninety adults with large cavities on the side of a back tooth will receive a standard filling, and the quality of the filling's shape and contact…

This study looks at blood samples from 84 children aged 4-17 having their tonsils removed to find chemical clues about why Black children often report more pain afterward. Researchers will measure pain scores and compare blood metabolites between racial groups. The goal is to und…

This early-phase study tests whether strawberry gummies can improve oral health in 36 adults, including smokers and non-smokers. Participants eat two types of gummies (real strawberry or placebo) four times daily for a week. Researchers measure how the body absorbs strawberry com…

This study looks at whether helping people with inflammatory arthritis address social needs—like food, housing, or transportation—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed appointments in the past year wil…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This study compares five different ways of using dental adhesives to repair worn teeth near the gum line (called non-carious cervical lesions). Thirty-four adults each received multiple fillings using different adhesive methods. The fillings were then checked after two years for …

This study compares two techniques for placing dental implants in people with no teeth: fully guided (using a surgical guide) and partially guided. Sixteen participants will receive implants in both jaws, and researchers will measure how accurate the implant positions are and how…

This study looks at whether certain inflammation markers in the blood can predict how well dental numbing shots work and how much pain people feel after treatment. Researchers will analyze blood samples from 150 adults with tooth inflammation (irreversible pulpitis) and compare t…

This study compares four new single-shade universal resin composites to a conventional composite for filling class 2 cavities (between teeth). 45 adults will receive 180 fillings, which will be evaluated at 6 and 12 months by blinded dentists using standard criteria. The goal is …