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New nanozyme treatment could revolutionize root canal disinfection

NCT ID NCT07518901

Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 01, 2026 · Updated 2 times

Summary

This study compares a new cleaning solution made from ferumoxytol nanozymes to the standard treatment for root canal infections. About 72 adults with infected teeth will receive either the new solution or the usual one during their root canal procedure. Researchers will measure how well each method kills bacteria and check healing with X-rays over two years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients willing to participate in the study. 2. Patients are 18 years or above. 3. Non-contributory medical history (Patient can be seen for regular dental appointment in PDM; ASA classes I and II). 4. Tooth requiring root canal treatment with radiographic presence of periapical radiolucency and 1. responding to thermal sensitivity testing negatively (Difluordichlormethane at 50 °C, Endo-Ice, 2. Coltène/Whaledent Inc., Cuyahoga Falls, Ohio) or a negative response to EPT testing. 5. Tooth with adequate remaining tooth structure for proper isolation with rubber dam. 6. No history of previous endodontic treatment on the tooth. 7. Teeth with single roots or multirooted teeth. Exclusion Criteria: 1. Self-reported pregnancy. 2. Patients requiring antibiotic premedication prior to dental treatment. 3. Patients with multiple drug allergies. 4. Patients with known hypersensitivity to Ferumoxytol nanoparticles or any iron products. 5. Patients who are scheduled for MRI for the head region within three months after Ferumoxytol nanoparticles application. 6. Periodontal changes (pockets 3 mm, mobility Grade I, or gingival edema). 7. Patients who cannot return for a subsequent appointment or follow-ups. 8. Radiographic presence of resorptive processes. 9. Cracked and fractured teeth.

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Conditions

The condition(s) this trial relates to.

dental abscess dental pulp disorder periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Endodontic disease Root canal infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Penn Dental Medicine, Department of Endodontics

    Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.