Can a special toothpaste keep your gums healthy?
NCT ID NCT07415733
First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 2 times
Summary
This study looks at whether a toothpaste with a special gum-health ingredient can improve gum health in people with gingivitis. 150 adults will use the test toothpaste for 13 weeks, then switch to a regular fluoride toothpaste for 4 weeks. Researchers will measure gum inflammation, bleeding, and plaque levels to see if the benefits last.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- toothpaste with gum-health active and fluoride
- What this could lead to
- If successful, this could show that using a toothpaste with a gum-health active helps control gum inflammation and bleeding better than fluoride alone.
- What could go wrong
- This is a small, early-stage study (150 people) testing a toothpaste, not a new drug. Results may not apply to everyone, and gum problems could return after switching toothpaste.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2026
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participants need to be competent i.e., able to understand what is to take place and able to provide a free decision on agreeing to the activity/taking part in the study on this. * Participants must be able to read and understand study instructions and any other relevant study documents. * Have at least 20 natural teeth without subgingival calculus, including 5 assessable teeth (excluding 3rd molars) in each quadrant. * Have a mean whole mouth BOP ≥ 10% at screening. * Willing to follow the lifestyle and dietary restrictions as detailed in the Information Sheet for study. Exclusion Criteria: * Be pregnant or breastfeeding. * Participants who participated in gum health study within 3 months prior to screening. * Current participation in any other cosmetic studies, any dental clinical studies or clinical trials. * Participants who have used any gum health products in the 4 weeks prior to screening. * Obvious signs of untreated caries or significant periodontal disease, which in the opinion of the study dentist, will affect either the scientific validity of the study or if the participant to take part in the study would affect their wellbeing. * Have more than three sites with a probing pocket depth (PPD) of ≥ 5 mm. * Full or partial dentures wearers. * Current orthodontic treatment. * Smokers or those who have a recent smoking history, including e-cigarettes. * Diabetics. * Have had a dental prophylaxis in the month prior to enrolment or have one scheduled prior to the end of the study. * Medical condition and/or regular use of any medication which might affect the outcome of the study, as determined by the study dentist, principally a course of anti-inflammatory, antimicrobial or statin drugs within 4 weeks of screening. * Taking dietary supplements (e.g. multivitamins, antioxidants, fish oils, etc.). * Known allergy to any ingredient in study products. * The participant is a Unilever employee or a member of the study team. * Any participant who, in the judgement of the investigator, should not participate in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Faculty of Dentistry, University of Indonesia
Jakarta Pusat, 10430, Indonesia
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Other studies related to the condition(s) this trial covers.
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