A simple marker might predict which teeth can be saved without root canal
NCT ID NCT06960603
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study tests whether the level of a specific inflammatory marker (MMP9) in the dental pulp can predict the success of a full pulpotomy, a procedure that removes the inflamed pulp from the crown of a tooth and seals it with a special material. Adults with deep cavities causing pulpitis in a molar will undergo the procedure, and their pain and healing will be tracked for up to two years. The goal is to see if measuring this marker during treatment can help identify which teeth are likely to heal successfully, potentially offering a less invasive alternative to root canal therapy.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Full pulpotomy procedure with calcium silicate capping material
- What this could lead to
- If successful, this could help dentists predict which teeth will respond well to a less invasive root canal alternative, potentially saving more natural teeth.
- What could go wrong
- This is a small, early-stage study. The marker may not reliably predict outcomes, and the procedure itself carries risks like infection or treatment failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2024
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Non -contributory medical history (ASA 1) * Molar tooth with deep caries extending\>= 2/3 of dentine or exposing the pulp on the radiograph * The tooth should give positive response to cold sensibility testing * Clinical diagnosis of either reversible or irreversible pulpitis based on the symptoms and results of cold testing. * The tooth is restorable, probing pocket depth and mobility are within normal limits Exclusion Criteria: * Non-restorable tooth. * Signs of pulpal necrosis including sinus tract or swelling. * No enough bleeding after the pulpotomy procedure. * Inability to achieve hemostasis within 10 min after the pulpotomy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Jordan university of science and Technology
Irbid, Irbid Governorate, 22110, Jordan