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New radiation method may spare patients painful mouth sores

NCT ID NCT02923570

First seen Nov 06, 2025 · Last updated May 21, 2026 · Updated 27 times

Summary

This study compares two types of radiation therapy for people with head and neck cancer: proton beam therapy and standard photon therapy (IMRT). The goal is to see if proton therapy causes fewer side effects, especially painful mouth sores. About 108 adults with certain cancers (like salivary gland, skin, or head and neck cancers) will take part. Both treatments are already used, but this is the first direct comparison to find out which is gentler on healthy tissue.

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Contacts and locations

Locations

  • Baptist Alliance MCI

    Miami, Florida, 33143, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

Conditions

Explore the condition pages connected to this study.