Can your own blood save a tooth? new study tests two natural gels for root regrowth
NCT ID NCT07460869
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests two treatments made from a child's own blood—concentrated growth factor (CGF) and platelet-rich fibrin (PRF)—to help regrow the roots of a damaged permanent molar. Sixty children with an immature, infected lower first molar will receive one of the two treatments during a root canal-like procedure. The goal is to see which gel works better at promoting root growth and saving the tooth.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- concentrated growth factor (CGF) and platelet-rich fibrin (PRF) from the patient's own blood
- What this could lead to
- If successful, this could offer a better way to help children's damaged permanent teeth regrow roots and avoid tooth loss.
- What could go wrong
- This is a small, early-stage study with only 60 participants, so results may not apply to all children. The treatment may not work as well as hoped, and there is a risk of infection or incomplete root growth.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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60 people
The number who actually took part.
- Started
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Jan 2025
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 to 8 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Children with immature necrotic lower fitrst permanent molar. * No history of repeated pathosis or cellulitis. * Patients accept the treatment modality. * Patient-free from systemic, allergic or genetic problems. Exclusion Criteria: * Tooth mobility. * Teeth with non-restorable crowns. * Children with facial cellulitis * Children with draining fistula * Children with a history of recurrent preapical pathosis
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of Dentistry Minya University
Minya, Minya Governorate, 2422998, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.