New tooth material could save Kids' teeth from root canals
NCT ID NCT07207382
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests three different materials used to treat deep cavities in children's permanent molars that are still growing. The goal is to see which material best keeps the tooth alive and allows the root to finish forming normally. Sixty-nine children aged 7 to 10 will receive one of the three materials after a partial pulp removal procedure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Treated Dentin Matrix, Premixed Bioceramic material, and Mineral Trioxide Aggregate (MTA)
- What this could lead to
- If successful, this could point toward a better, more natural material for treating deep cavities in children's teeth, helping to keep the tooth alive and growing.
- What could go wrong
- This is a relatively small trial (69 participants) and compares materials already in use, so major breakthroughs are unlikely. The new material may not perform better than existing options.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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69 people
The number who actually took part.
- Started
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Feb 2024
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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7 to 10 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Children aged between 7 and 10 years-old. * Vital permanent first molars with deep caries lesion approaches the pulp without symptoms of irreversible pulpitis, with open apices in the radiograph. * Permanent first molars with pulpal exposure that occurred during caries excavation. * Incompletely formed roots Exclusion Criteria: * Teeth with signs and symptoms of chronic infection such as swelling and mobility. * Teeth with excessive bleeding from amputated radicular stumps * Teeth showing radiographic evidence of pathologic root resorption, inter-radicular bone loss, periapical pathology and calcifications in the canals. * Lack of patient/parent compliance and cooperation. * Children who are physically or mentally disabled or having any medical condition that will complicate the treatment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ain Shams University
Cairo, Egypt