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Can a simple rinse stop the most painful complication of wisdom tooth surgery?

NCT ID NCT07814430

Prevention Sponsor: CMH Lahore Medical College and Institute of Dentistry Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 15, 2026 · Updated 2 times

Summary

Removing an impacted lower wisdom tooth can leave a painful complication called dry socket, where the protective blood clot in the empty socket breaks down. This trial compares two liquids used to rinse the socket right after extraction: normal saline and chlorhexidine, an antiseptic. Researchers randomly assign 174 adults to one rinse or the other and check them on days 2, 3, and 5 for signs of dry socket and pain. The goal is to learn whether chlorhexidine lowers the rate of dry socket compared with saline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
chlorhexidine, an antiseptic mouth rinse used to irrigate the tooth socket
What this could lead to
If chlorhexidine works better than saline, dentists could adopt a simple, low-cost rinse to spare patients the pain of dry socket after wisdom tooth surgery.
What could go wrong
Dry socket is uncommon, so the trial needs enough participants to show a real difference. Chlorhexidine can irritate tissue or stain teeth, and results from one surgeon's practice may not apply everywhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

174 people

The number who actually took part.

Started

Feb 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged 18 to 50 years. 2. Patients requiring surgical extraction of an impacted lower third molar (lower wisdom tooth). 3. Impacted lower third molars classified as having slight to moderate difficulty according to Pederson's scale. 4. Patients classified as American Society of Anesthesiologists (ASA) physical status I or II. 5. Patients of either biological sex. 6. Patients who provide written informed consent to participate in the study. Exclusion Criteria: 1. Systolic blood pressure ≥160 mmHg. 2. Diastolic blood pressure ≥100 mmHg. 3. Current smokers. 4. Alcohol use. 5. Patients with muscular diseases. 6. Patients currently taking antibiotics or anti-inflammatory medications. 7. Patients with physical or mental disabilities that would prevent participation in the study or completion of follow-up assessments. 8. Patients requiring extraction without bony osteotomy. 9. Deep or very difficult impactions according to Pederson's scale.

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Conditions

The condition(s) this trial relates to.

alveolar periostitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar osteitis Impacted lower third molar

Contacts and locations

Locations

  • CMH Lahore

    Lahore, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.