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Your own blood may be the key to easier wisdom tooth recovery

NCT ID NCT07742826

Symptom relief Sponsor: Final International University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether a special blood clot called platelet-rich fibrin (PRF), made from a patient's own blood, can reduce pain, swelling, and jaw stiffness after impacted wisdom tooth surgery. It compares PRF alone, PRF plus a corticosteroid injection, and standard care in 60 adults. Participants are randomly assigned to one of three groups, and their recovery is tracked for a week. The goal is to see if PRF, with or without the steroid, offers better relief than usual treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich fibrin (PRF) prepared from the participant's own blood, with or without a single dose of dexamethasone (corticosteroid), compared to standard care.
What this could lead to
If PRF proves effective, it could offer a natural, low-cost way to ease pain and swelling after wisdom tooth removal, potentially reducing the need for steroids.
What could go wrong
This is a small, early-stage trial (60 people) and results may not apply to everyone. PRF's benefits are uncertain, and adding a corticosteroid carries risks like infection or delayed healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 years and older. * Patients with good general health * Patients with complete clinical and radiographic examination (panoramic radiograph/CBCT if applicable) * Patients willing and able to attend all postoperative follow-up visits Exclusion Criteria: * Patients with systemic diseases that may impair wound healing (e.g., uncontrolled diabetes, immunodeficiency). * Pregnant or breastfeeding women. * Patients with acute infection, abscess, or pericoronitis at the surgical site. * Patients with a history of allergy or contraindication to corticosteroids, local anesthetics, or prescribed medications. * Patients using corticosteroids, anticoagulants, immunosuppressive drugs, or bisphosphonates. * Patients with bleeding disorders. * Patients with previous radiotherapy to the head and neck region. * Patients unable or unwilling to comply with the study protocol or attend follow-up visits.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative Postoperative Complications Trismus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted lower third molar Impacted mandibular third molar extraction Impacted wisdom tooth

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Final International University Faculty of Dentistry

    RECRUITING

    Nicosia, 2323, Cyprus

More trials for these conditions

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