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Wisdom tooth pain relief: which steroid works best?

NCT ID NCT07628166

Symptom relief Sponsor: Irfan Üstündağ Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two common steroids, dexamethasone and methylprednisolone, to see which better reduces pain and facial swelling after impacted wisdom tooth surgery. Sixty healthy adults aged 18-35 had their tooth removed and received either a steroid injection or no injection. The researchers measured swelling with a smartphone 3D scanner and pain using a standard scale. The goal is to find the best option for a smoother recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone and methylprednisolone (steroid injections)
What this could lead to
If one steroid works better, it could lead to a standard recommendation for reducing pain and swelling after wisdom tooth surgery.
What could go wrong
This is a small, single-center study with only 60 participants. Results may not apply to all patients or surgeries, and the effect may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Mar 2026

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. Systemically healthy individuals classified as ASA I according to the American Society of Anesthesiologists. 2\. Patients between 18 and 35 years of age. 3. Presence of a unilateral, fully bone-impacted mandibular third molar with an indication for surgical extraction. 4\. Impacted teeth classified as Class II or III and Position B or C according to the Pell-Gregory classification system. 5\. Impacted teeth with mesioangular or vertical angulation based on Winter's classification. 6\. A moderate surgical difficulty level (score of 5 to 7) confirmed via the Pederson difficulty index. 7\. Competency to provide written informed consent and willingness to adhere to follow-up schedules. Exclusion Criteria: * 1\. Presence of any systemic disease or medical condition that contraindicates the use of systemic or local corticosteroids. 2\. Pregnancy or lactation. 3. Active pericoronitis, acute infection, or pathology (e.g., cysts, tumors) associated with the target third molar or adjacent structures. 4\. Use of antibiotics, systemic corticosteroids, or regular anti-inflammatory medications within the past 30 days prior to surgery. 5\. History of daily tobacco smoking within the past 6 months. 6. Known allergy or hypersensitivity to local anesthetics, dexamethasone, methylprednisolone, or the prescribed postoperative medications (amoxicillin, clavulanic acid, paracetamol, dexketoprofen). 7\. Inability to comply with the 3D facial scanning protocols or postoperative follow-up appointments.

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Conditions

The condition(s) this trial relates to.

Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted mandibular third molar extraction Postoperative edema and pain Postoperative pain control

Contacts and locations

Locations

  • Inonu University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery

    Malatya, Malatya, 44050, Turkey (Türkiye)

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