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Ozone gas may ease pain after wisdom tooth surgery

NCT ID NCT06802354

Symptom relief Sponsor: Jelena Krunic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 3 trial tested whether applying gaseous ozone to the extraction site after impacted wisdom tooth surgery can reduce common complications like pain, swelling, and difficulty opening the mouth. Twenty adults with similar wisdom tooth impactions received either ozone or a sham treatment for 30 seconds. Researchers measured pain, swelling, and healing over a week, and also tracked quality of life. The goal is to see if ozone can make recovery smoother.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
gaseous ozone
What this could lead to
If it works, this could offer a simple, low-cost way to reduce pain and swelling after wisdom tooth surgery.
What could go wrong
This is a very small trial with only 20 participants, so results may not apply to everyone. Ozone also has known risks for certain medical conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

20 people

The number who actually took part.

Started

Dec 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients over 18 years * Patients with bilaterally impacted mandibular third molars classified as impaction index II B * Patients in good general health (based on the ASA classification as ASA I and ASA II). Exclusion Criteria: * Contraindications for ozone application (pregnancy, hyperthyroidism, favism, anemia, myasthenia, bleeding disorders, alcohol intoxication, myocardial infarction, pacemaker, allergy to ozone) * Patients who have used corticosteroid and antibiotic therapy in the last three months prior to inclusion in the study * Patients with signs of local inflammation in the oral cavity * Female patients during pregnancy and breastfeeding.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted mandibular third molar extraction

Contacts and locations

Locations

  • University of East Sarajevo, Faculty of Medicine

    Foca, Republika Srpska, 73300, Bosnia and Herzegovina

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