Ozone gas may ease pain after wisdom tooth surgery

NCT ID NCT06802354

Completed Symptom relief Sponsor: Jelena Krunic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 3 trial tested whether applying gaseous ozone to the extraction site after impacted wisdom tooth surgery can reduce common complications like pain, swelling, and difficulty opening the mouth. Twenty adults with similar wisdom tooth impactions received either ozone or a sham treatment for 30 seconds. Researchers measured pain, swelling, and healing over a week, and also tracked quality of life. The goal is to see if ozone can make recovery smoother.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: gaseous ozone
What this could lead to: If it works, this could offer a simple, low-cost way to reduce pain and swelling after wisdom tooth surgery.
What could go wrong: This is a very small trial with only 20 participants, so results may not apply to everyone. Ozone also has known risks for certain medical conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMPACTED MANDIBULAR THIRD MOLAR EXTRACTION

Contacts and locations

Locations

University of East Sarajevo, Faculty of Medicine

Foca, Republika Srpska, 73300, Bosnia and Herzegovina

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