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Blood clot and laser combo may tame wisdom tooth pain

NCT ID NCT07748585

Symptom relief Sponsor: NEW Cyprus Health and Social Sciences University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests whether placing a special blood-derived clot (titanium-prepared platelet-rich fibrin) in the socket and applying low-level laser therapy can reduce pain, swelling, jaw stiffness, and painkiller use after impacted wisdom tooth removal. Sixty adults having a lower wisdom tooth extracted will be randomly assigned to receive one of these treatments, both, or neither. The study measures recovery over the following days to see if these approaches improve healing and comfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Titanium-prepared platelet-rich fibrin (T-PRF) placed in the extraction socket, and low-level laser therapy applied to the surgical area.
What this could lead to
If effective, these approaches could offer a drug-free way to ease pain, swelling, and jaw stiffness after wisdom tooth surgery, potentially reducing the need for painkillers.
What could go wrong
This is a small, early-stage trial, and results may not apply to everyone. The procedures carry typical surgical risks, and the added benefits over standard care are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Dec 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 31 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults requiring surgical extraction of a unilateral vertically impacted mandibular third molar. * Healthy individuals (ASA I or II). * Ability to provide written informed consent. * Willingness to attend all follow-up visits. Exclusion Criteria: * Systemic disease affecting wound healing. * Pregnancy or lactation. * Active infection or acute pericoronitis. * Long-term opioid use. * Smoking and alcohol use. * Known allergy to study medications. * Previous radiotherapy to the head and neck region * Inability to attend follow-up visits.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted mandibular third molar extraction

Contacts and locations

Locations

  • Cyprus Health and Social Sciences University, Faculty of Dentistry

    Güzelyurt, Güzelyurt, 99700, Turkey (Türkiye)

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