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New study tests four rinse methods to ease root canal pain

NCT ID NCT07623629

Symptom relief Sponsor: Future University in Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares four different rinsing tools used after root canal treatment to see which one reduces pain the most. Fifty-two adults with an infected lower back tooth will be randomly assigned to one of four groups. They will rate their pain at several times over two days and record how many painkillers they take. The goal is to find a simple way to make root canals more comfortable.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
root canal treatment with different final irrigation methods (standard needle, vibration device, vacuum device, or combination)
What this could lead to
If one rinsing method works better, dentists may adopt it to make root canals less painful for patients.
What could go wrong
This is a small, early-stage study with only 52 people, so results may not apply to everyone. Pain is subjective and hard to measure precisely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

52 people

The number who actually took part.

Started

Jan 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Lower first molar Classification of root canal configuration according to weine classification: - * Distal root: any type of root canal configuration given that the portal of exit is through only one apical foramen * Mesial root: any type of root canal configuration given that the portal of exit is through only one apical foramen(18). * Patient with mild pre-operative pain with pain score from 0-3 * Medically free patients with no systemic disease: (American Society of Anesthesiologists / (ASA Class I or II). * The age range is between 20 to 40 years. * Patients have restorable lower permanent molars that were diagnosed with symptomatic apical periodontitis with small to moderate periapical lesion. * Positive patient's acceptance for participating in the study. * Patients able to sign informed consent. Exclusion Criteria: * Patients with systemic conditions that may affect pain perception (e.g., fibromyalgia, chronic pain disorders) * Patients currently taking or taken analgesics or anti-inflammatory medications before the trial in the last 12 hours. * Pregnant or lactating females. * Psychologically disturbed patients. * Patients with a history of allergy to any medication used in the study are excluded. Teeth that have: * Periodontally affected with grade 2 or 3 mobility. * Not restorable teeth. * Abnormal anatomy and calcified canals. * Previous root canal treatment. * Any patient that matched the inclusion criteria, however had an unintentional errors during procedure, eg: over-instrumentation/over-obturation.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis Pain, Postoperative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Necrotic pulp with symptomatic apical periodontitis

Contacts and locations

Locations

  • Future University in Egypt

    Cairo, New Cairo, 11835, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.