Nanoparticles may ease root canal pain, study hopes
NCT ID NCT07327996
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding tiny antibacterial particles called mesoporous silica nanoparticles to standard root canal medication can reduce pain and kill more bacteria. Forty-two adults with infected lower molar teeth will receive one of three treatments: standard medication, nanoparticles alone, or a mix of both. Pain is measured over 72 hours and bacteria levels are checked before and after treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- mesoporous silica nanoparticles combined with calcium hydroxide
- What this could lead to
- If it works, this could lead to a more effective root canal treatment that causes less pain and reduces infection.
- What could go wrong
- This is a small, early-stage trial with only 42 people, so results may not apply to everyone. The nanoparticles are new and their long-term safety is unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 42 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Sep 2025
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Inclusion Criteria: 1. Patients with an age range between 18 to 40. 2. No sex predilection. 3. Patients with necrotic pulp. 4. Patients able to sign informed consent. 5. Restorable teeth. 6. Positive patient's acceptance for participating in the study. 7. Type III distal and mesial canal of first mandibular molar. * Exclusion Criteria: 1. Pregnant females 2. Medically compromised patients. 3. Patients having analgesics before the treatment 4. If antibiotics have been administrated during the past two weeks pre-operatively. 5. Patients having bruxism or clenching 6. Patients having sever malocclusion associated with traumatic occlusion. 7. Teeth that have: 1. Peri-apical radiolucency 2. Root resorption. 3. Pulp stones or calcifications. 4. Previous endodontic treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Future University in Egypt
Cairo, New Cairo, 11835, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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