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Could cold plasma make root canals less painful?

NCT ID NCT07747753

Disease control Sponsor: Ahmed Hesham Abdelmohaimen Rezk Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests whether cold atmospheric plasma can match standard sodium hypochlorite irrigation for disinfecting root canals in teeth with dead nerves. Sixty adults with a single necrotic tooth will receive one of the two treatments. Researchers will compare post-treatment pain levels and a healing marker called MMP-9 to see if plasma offers a comparable or better experience.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cold atmospheric plasma applied as a root canal disinfectant
What this could lead to
If cold plasma works as well as standard irrigation, it could offer a gentler alternative for root canal treatment, potentially reducing post-procedure pain.
What could go wrong
This is a small, early-stage trial, and cold plasma may not match the effectiveness of standard disinfectants. There is also a risk of increased pain or infection if disinfection is less effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients in good physical health; American Society of Anesthesiologists (ASA) class I or II, with no known allergic manifestations to the drugs used in the study and no involvement with other medication during the study (Appendix) 2. Patient's age between 18-55 years. 3. Male and female patients. 4. Patients who can understand the numerical rating scale (Appendix 4). 5. Patients who accept to participate in the trial and can sign the informed consent (Appendix 1). 6. Mature mandibular premolar teeth with: * Negative response to electric pulp tester. * No intra-canal calcifications or internal resorptive lesions. Exclusion Criteria: 1. Medically compromised patients having substantive functional limitations (ASA III or IV) (Appendix 2). 2. Patients having two or more adjacent teeth requiring endodontic treatment. 3. Patients who received antibiotic therapy within the last three months before treatment (Rôças et al., 2016). 4. Patients administered analgesics in the last 24 hours before treatment. 5. Teeth with: * Vital pulps. * Immature apices. * Acute periapical abscess, swellings and facial cellulitis. * Periodontally affected (mobility grade II or III). * Previous root canal treatment. * Non-restorable coronal portion. 6. TMJ problems, bruxism or traumatic occlusion. 7. Inability to perceive the given instructions.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Necrotic pulp

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of dentistry, Cairo University

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.