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Could melatonin be the new toothache soother?

NCT ID NCT07495605

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a 1% melatonin gel to a standard calcium hydroxide paste placed inside the tooth after root canal cleaning. It aims to see which one better reduces pain, lowers bacteria, and affects a certain protein linked to healing. The trial will involve 50 adults with a dead nerve in a lower premolar tooth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 18-50 years old. 2. Males and females. 3. Healthy patients categorized as I or II according to The American Society of Anesthesiologists. (ASA I or II), with no underlying allergies. 4. Single-rooted mandibular premolar teeth, having single root canal: diagnosed clinically with pulp necrosis. 5. Patients accepting to participate in the trial. 6. Patients who can understand pain scale (Appendix I) and can sign the informed consent (Appendix II). Exclusion Criteria: 1. Medically compromised patients having significant systemic disorders (ASA III or IV). 2. Pregnant females. 3. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception. 4. Teeth with multiple canals. 5. Teeth that show association with acute periapical abscess or swelling. 6. Teeth with vital pulp. 7. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam. 8. Immature teeth. 9. Teeth with greater than grade I mobility or pocket depth greater than 4 mm. 10. Teeth showing radiographic evidence of external or internal root resorption, vertical root fracture, perforation or calcification. 11. Patients with two or more adjacent teeth requiring endodontic treatment. 12. Patients reporting bruxism, clenching or TMJ problems. 13. Teeth with previous endodontic treatment. 14. Inability to perceive the given instructions.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intensity of postoperative pain, bacterial load reduction and periapical MMP-9 levels in patients with necrotic pulp

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.