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Sound waves and suction may improve root canal healing, study suggests
NCT ID NCT07589556
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This trial tests four methods of activating the cleaning liquid during root canal treatment in adults aged 20 to 40 with an infected lower first molar. The goal is to see which method helps the infection at the root tip heal best after 12 months. Participants receive one-visit root canal treatment and are followed with check-ups and a 3D dental scan.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- root canal treatment with different irrigation activation methods (standard syringe, Ultra X, Endo Vac, I Vac)
- What this could lead to
- If successful, this could identify the best way to clean root canals, leading to faster and more complete healing of tooth infections.
- What could go wrong
- This is a small, early-stage trial with only 52 participants, so results may not apply to everyone. The different irrigation methods may show no clear advantage over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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52 people
The number who actually took part.
- Started
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Jan 2025
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \- Medically free patients with no systemic disease: (American Society of Anesthesiologists / (ASA Class I or II). * The age range is between 20 to 40 years. * Patients have restorable Mandibular permanent molars that were diagnosed with necrotic pulp with symptomatic apical periodontitis (with small to moderate periapical lesion/≤ 5mm) . * Positive patient's acceptance for participating in the study. * Patients able to sign informed consent. * Both male and female patients are eligible. * Good oral hygiene. * Mandibular first molars with two roots (mesial and distal), each presenting a Weine Type III canal configuration. Exclusion Criteria: * \- Medically compromised patients. * Pregnant or lactating females. * Psychologically disturbed patients. * Patients with a history of allergy to any medication used in the study were excluded. * Mandibular first molar with: * Wide or open apex. * Vital pulp tissues. * Periodontally affected with grade 2 or 3 mobility. * Not restorable teeth. * Abnormal anatomy and calcified canals. * Previous root canal treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Future university in Eygpt
Cairo, New Cairo, 118535, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.