Can a targeted antibody boost Radiation's power against head and neck cancer?

NCT ID NCT00956007

Disease control Sponsor: Radiation Therapy Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase III trial studies whether adding the drug cetuximab to modern radiation therapy improves survival for people with advanced head and neck cancer that has been surgically removed. About 700 participants received either radiation alone or radiation plus cetuximab. The study tracks overall survival and side effects like swallowing difficulty and skin reactions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: cetuximab (a monoclonal antibody) given intravenously, plus intensity-modulated radiation therapy
What this could lead to: If successful, adding cetuximab to radiation could improve survival and reduce recurrence for people with advanced head and neck cancer after surgery.
What could go wrong: This is a large phase III trial, but results are not yet final. Adding cetuximab may increase side effects like skin toxicity and swallowing problems without guaranteeing better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

702 people

The number who actually took part.

Started

Mar 2010

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Conditions for Patient Eligibility: * Pathologically (histologically) proven diagnosis of squamous cell carcinoma (including variants such as verrucous carcinoma, spindle cell carcinoma, carcinoma NOS \[not otherwise specified\], etc.) of the head/neck (oral cavity, oropharynx or larynx); Note: Hypopharynx primaries are excluded because these patients have both a poor prognosis and high likelihood of post- radiation complications. * Clinical stage T1, N1-2 or T2-4a, N0-2, M0 including no distant metastases, based upon the following minimum diagnostic workup: * General history and physical examination by a radiation oncologist and/or medical oncologist within 8 weeks prior to registration; * Examination by an otolaryngologists or Head \& Neck Surgeon, within 8 weeks prior to registration; a laryngopharyngoscopy (mirror and/or fiberoptic and/or direct procedure) is recommended but not required. * Chest x-ray (at a minimum) or chest computed tomography (CT) scan (with or without contrast) or CT/positron emission tomography (PET) of chest (with or without contrast) within 8 weeks prior to registration. * Gross total resection of the primary tumor with curative intent must be completed within 7 weeks of registration with surgical pathology demonstrating one or more of the following intermediate risk factors: * Perineural invasion; * Lymphovascular invasion; * Single lymph node \> 3 cm or ≥ 2 lymph nodes (all \< 6 cm) \[no extracapsular extension\]; * Close margin(s) of resection, defined as cancer extending to within 5 mm of a surgical margin, and/or an initially focally positive margin that is subsequently superseded by intraoperative negative margins. Similarly, patients whose tumors had focally positive margins in the main specimen but negative margins from re-excised samples in the region of the positive margin are eligible. * Pathologically confirmed T3 or T4a primary tumor. * T2 oral cavity cancer with \> 5 mm depth of invasion. * Zubrod Performance Status of 0-1 within 2 weeks prior to registration; * Age ≥ 18; * Complete blood count (CBC)/differential obtained within 4 weeks prior to registration on study, with adequate bone marrow function defined as follows: * Absolute granulocyte count (AGC) ≥ 1,500 cells/mm3; * Platelets ≥ 100,000 cells/mm3; * Hemoglobin (Hgb) ≥ 8.0 g/dl (Note: The use of transfusion or other intervention to achieve Hgb ≥8.0 g/dl is acceptable). * Adequate hepatic function, defined as follows: * Total bilirubin \< 2 x institutional upper limit of normal (ULN) within 2 weeks prior to registration; * aspartate aminotransferase (AST) or alanine transaminase (ALT) \< 3 x institutional ULN within 2 weeks prior to registration. * Adequate renal function, defined as follows: * Serum creatinine (Scr) \< 2 x institutional ULN within 2 weeks prior to registration or; creatinine clearance (CCr) ≥ 50 ml/min within 2 weeks prior to registration determined by 24-hour collection or estimated by Cockcroft-Gault formula: CCr male = \[(140 - age) x (weight in kg)\] /\[(SCr mg/dl) x (72)\] CCr female = 0.85 x (CCr male) * Negative serum pregnancy test within 2 weeks prior to registration for women of childbearing potential; * The following assessments are required within 2 weeks prior to the start of registration: Na, K, Cl, glucose, Ca, Mg, and albumin. Note: Patients with an initial magnesium \< 0.5 mmol/L (1.2 mg/dl) may receive corrective magnesium supplementation but should continue to receive either prophylactic weekly infusion of magnesium and/or oral magnesium supplementation (e.g., magnesium oxide) at the investigator's discretion. * Women of childbearing potential and male participants who are sexually active must agree to use a medically effective means of birth control; * Patients must provide study specific informed consent prior to study entry, including consent for mandatory tissue submission for EGFR and for oropharyngeal patients, HPV analyses. Conditions for Patient Ineligibility * Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years; noninvasive cancers (For example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible) are permitted even if diagnosed and treated \< 3 years ago. Patients with simultaneous primaries or bilateral tumors are excluded, with the exception of patients with bilateral tonsil cancers or patients with T1-2, N0, M0 resected differentiated thyroid carcinoma, who are eligible. * Per the operative and/or pathology report, positive margin(s) \[defined as tumor present at the cut or inked edge of the tumor\], nodal extracapsular extension, and/or gross residual disease after surgery; Note: Patients whose tumors had focally positive margins in the main specimen but negative margins from re-excised samples in the region of the positive margin are eligible. * Prior systemic chemotherapy or anti-EGF therapy for the study cancer; note: prior chemotherapy or anti-EGF therapy for a different cancer is allowable. * Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields; * Severe, active co-morbidity, defined as follows: * Unstable angina and/or congestive heart failure requiring hospitalization within 6 months prior to registration; * Transmural myocardial infarction within 6 months prior to registration; * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration; * Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration; * Idiopathic pulmonary fibrosis or other severe interstitial lung disease that requires oxygen therapy or is thought to require oxygen therapy within 1 year prior to registration; * Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol. * Acquired Immune Deficiency Syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note: HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is necessary because the treatments involved in this protocol may be significantly immunosuppressive. Protocol-specific requirements may also exclude immuno-compromised patients. * Grade 3-4 electrolyte abnormalities (CTCAE v4): * Serum calcium (ionized or adjusted for albumin) \< 7 mg/dl (1.75 mmol/L) or \>12.5 mg/dl (\> 3.1 mmol/L) despite intervention to normalize levels; * Glucose \< 40 mg/dl (\< 2.2 mmol/L) or \> 250 mg/dl (\> 14mmol/L); * Magnesium \< 0.9 mg/dl (\< 0.4 mmol/L) or \> 3 mg/dl (\> 1.23 mmol/L) despite intervention to normalize levels; * Potassium \< 3.0 mmol/L or \> 6 mmol/L despite intervention to normalize levels; * Sodium \< 130 mmol/L or \> 155 mmol/L despite intervention to normalize levels. * Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic. * Prior allergic reaction to cetuximab.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck tongue cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck cancer

Contacts and locations

Locations

Adams Cancer Center

Gettysburg, Pennsylvania, 17325, United States
Akron General Medical Center

Akron, Ohio, 44307, United States
Albert Einstein Medical Center

Philadelphia, Pennsylvania, 19141, United States
Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada
AnMed Health Cancer Center

Anderson, South Carolina, 29621, United States
Arizona Oncology Associates-West Orange Grove

Tucson, Arizona, 85704, United States
Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States
Atlanta VA Medical Center

Decatur, Georgia, 30033, United States
Baptist Hospital of Miami

Miami, Florida, 33176, United States
Barnes-Jewish West County Hospital

St Louis, Missouri, 63141, United States
Bay Area Medical Center

Marinette, Wisconsin, 54143, United States
Bay Area Tumor Institute CCOP

Oakland, California, 94609, United States
Ben Taub General Hospital

Houston, Texas, 77030, United States
Beth Israel Medical Center

New York, New York, 10003, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
CHUM - Hopital Notre-Dame

Montreal, Quebec, H2L 4M1, Canada
CHUQ - Pavilion Hotel-Dieu de Quebec

Québec, Quebec, G1R 2J6, Canada
Cancer Care Centers of South Texas- Northeast

San Antonio, Texas, 78217, United States
Cancer Care Northwest - Spokane South

Spokane, Washington, 99202, United States
Cancer Care Northwest-North Spokane

Spokane, Washington, 99218, United States
Cancer Centers of North Carolina

Raleigh, North Carolina, 27607, United States
CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada
Cape Radiation Oncology

Cape Girardeau, Missouri, 63703, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Central Maine Medical Center

Lewiston, Maine, 04240, United States
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, J1H 5N4, Canada
Cherry Tree Cancer Center

Hanover, Pennsylvania, 17331, United States
Chinese University of Hong Kong-Prince of Wales Hospital

Shatin, Hong Kong, OX1 3UJ, China
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
City of Hope

Duarte, California, 91010, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Clement J. Zablocki VA Medical Center

Milwaukee, Wisconsin, 53295, United States
Cleveland Clinic Cancer Center Independence

Independence, Ohio, 44131, United States
Cleveland Clinic Cancer Center-Strongsville

Strongsville, Ohio, 44136, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic Wooster Specialty Center

Wooster, Ohio, 44691, United States
Community Regional Cancer Care-East Radiation Oncology

Indianapolis, Indiana, 46219, United States
Community Regional Cancer Care-North

Indianapolis, Indiana, 46256, United States
Compass Oncology Vancouver

Vancouver, Washington, 98684, United States
Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Dixie Medical Center Regional Cancer Center

St. George, Utah, 84770, United States
Doctor H. Bliss Murphy Cancer Centre

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Door County Cancer Center

Sturgeon Bay, Wisconsin, 54235-1495, United States
Emory University/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Exeter Hospital

Exeter, New Hampshire, 03833, United States
Florida Hospital

Orlando, Florida, 32803, United States
Flower Hospital

Sylvania, Ohio, 43560, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County

Mount Holly, New Jersey, 08060, United States
Fox Valley Hematology and Oncology

Appleton, Wisconsin, 54911-3496, United States
Froedtert and the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Geaugra Hospital

Chardon, Ohio, 44024, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822-2001, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Greenville Health System Cancer Institute-Faris

Greenville, South Carolina, 29605, United States
Greenville Health System Cancer Institute-Spartanburg

Spartanburg, South Carolina, 29307, United States
Greenville Health System Cancer Institute/Greenville CCOP

Greenville, South Carolina, 29615, United States
Gundersen Lutheran

La Crosse, Wisconsin, 54601, United States
Harrison Medical Center

Bremerton, Washington, 98310, United States
Health Sciences North

Greater Sudbury, Ontario, P3E 5J1, Canada
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Highland Hospital

Rochester, New York, 14620, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Hines Veterans Administration Hospital

Hines, Illinois, 60141, United States
Hunter Holmes McGuire Veterans Administration Medical Center

Richmond, Virginia, 23249, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
IU Health Ball Memorial Hospital

Muncie, Indiana, 47303, United States
IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States
Ingalls Memorial Hospital

Harvey, Illinois, 60426, United States
Intermountain Medical Center

Murray, Utah, 84157, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612-3785, United States
Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kansas City Cancer Center-Lee's Summit

Lee's Summit, Missouri, 64064, United States
Kansas City Cancer Centers - North

Kansas City, Missouri, 64154, United States
King Faisal Specialist Hospital and Research Centre

Riyadh, 11211, Saudi Arabia
Kinston Medical Specialists PA

Kinston, North Carolina, 28501, United States
LDS Hospital

Salt Lake City, Utah, 84143, United States
Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Lake University Ireland Cancer Center

Mentor, Ohio, 44060, United States
Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States
Lehigh Valley Hospital

Allentown, Pennsylvania, 18105, United States
London Regional Cancer Program

London, Ontario, N6A 4L6, Canada
Los Angeles County-USC Medical Center

Los Angeles, California, 90033, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
MD Anderson Cancer Center at Cooper-Voorhees

Voorhees Township, New Jersey, 08043, United States
Maimonides Medical Center

Brooklyn, New York, 11219, United States
Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
McFarland Clinic PC-William R Bliss Cancer Center

Ames, Iowa, 50010, United States
McGill University Department of Oncology

Montreal, Quebec, H2W 1S6, Canada
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Health University Medical Center

Savannah, Georgia, 31403, United States
Memorial Hermann Memorial City Medical Center

Houston, Texas, 77024, United States
Memorial Medical Center

Modesto, California, 95355, United States
Memorial Medical Center

Springfield, Illinois, 62781-0001, United States
Memorial Sloan Kettering Cancer Center Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Cancer Center at Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan-Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan-Kettering Cancer Center Rockville Centre

Rockville Centre, New York, 11570, United States
Memorial Sloan-Kettering Cancer Center at Sleepy Hallow

Sleepy Hollow, New York, 10591, United States
Mercy Cancer Center-Elyria

Elyria, Ohio, 44035, United States
Mercy General Hospital Radiation Oncology Center

Sacramento, California, 95819, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Medical Center

Canton, Ohio, 44708, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy San Juan Medical Center

Carmichael, California, 95608, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Mission Hospital-Memorial Campus

Asheville, North Carolina, 28801, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
New York Oncology Hematology PC - Albany

Albany, New York, 12206, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States
Northeast Georgia Medical Center

Gainesville, Georgia, 30501, United States
Northeast Radiation Oncology Center

Dunmore, Pennsylvania, 18512, United States
Northwest CCOP

Tacoma, Washington, 98405, United States
Oakwood Hospital

Dearborn, Michigan, 48124, United States
Ohio State University Medical Center

Columbus, Ohio, 43210, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Ottawa Health Research Institute-General Division

Ottawa, Ontario, K1H 1C4, Canada
Parkview Hospital Randallia

Fort Wayne, Indiana, 46805, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
Peninsula Regional Medical Center

Salisbury, Maryland, 21801, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States
Pomona Valley Hospital Medical Center

Pomona, California, 91767, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Portland Veterans Administration Medical Center

Portland, Oregon, 97239, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Radiation Oncology Associates PC

Fort Wayne, Indiana, 46804, United States
Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Renown Regional Medical Center

Reno, Nevada, 89502, United States
Robinson Radiation Oncology

Ravenna, Ohio, 44266, United States
Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States
Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Saint Alphonsus Regional Medical Center

Boise, Idaho, 83706, United States
Saint Charles Hospital

Oregon, Ohio, 43616, United States
Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States
Saint Helena Hospital

St. Helena, California, 94574, United States
Saint John Hospital and Medical Center

Detroit, Michigan, 48236, United States
Saint John Macomb-Oakland Hospital

Warren, Michigan, 48093, United States
Saint John's Hospital

Springfield, Illinois, 62702, United States
Saint John's Mercy Medical Center

St Louis, Missouri, 63141, United States
Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106-0995, United States
Saint Joseph's-Candler Health System

Savannah, Georgia, 31405, United States
Saint Louis University Hospital

St Louis, Missouri, 63110, United States
Saint Luke's Hospital of Duluth

Duluth, Minnesota, 55805, United States
Saint Mary Medical and Regional Cancer Center

Langhorne, Pennsylvania, 19047, United States
Saint Mary's of Michigan

Saginaw, Michigan, 48601, United States
Saint Peter's University Hospital

New Brunswick, New Jersey, 08901, United States
Saint Vincent Hospital

Green Bay, Wisconsin, 54301, United States
Saint Vincent's Medical Center

Bridgeport, Connecticut, 06606, United States
Salem Hospital

Salem, Oregon, 97301, United States
Sands Cancer Center

Canandaigua, New York, 14424, United States
Sanford Cancer Center-Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sentara Cancer Institute at Sentara CarePlex Hospital

Hampton, Virginia, 23666, United States
Sentara Hospitals

Norfolk, Virginia, 23507, United States
Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, 23454, United States
Singing River Hospital

Pascagoula, Mississippi, 39581, United States
Siouxland Hematology Oncology Associates

Sioux City, Iowa, 51101, United States
Siteman Cancer Center - Saint Peters

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Skagit Valley Hospital

Mount Vernon, Washington, 98274, United States
Southwest General Health Center Ireland Cancer Center

Middleburg Heights, Ohio, 44130, United States
Sparta Cancer Treatment Center

Sparta, New Jersey, 07871, United States
Spartanburg Regional Medical Center

Spartanburg, South Carolina, 29303, United States
Stanford University Hospitals and Clinics

Stanford, California, 94305, United States
Summa Akron City Hospital/Cooper Cancer Center

Akron, Ohio, 44304, United States
Summa Barberton Hospital

Barberton, Ohio, 44203, United States
Summa Health Center at Lake Medina

Medina, Ohio, 44256, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Cancer Centers Radiation Oncology Services-Vacaville

Vacaville, California, 95687, United States
Sutter General Hospital

Sacramento, California, 95816, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
Texas Cancer Center-Sherman

Sherman, Texas, 75090, United States
Texas Oncology - Central Austin Cancer Center

Austin, Texas, 78731, United States
Texas Oncology - Round Rock Cancer Center

Round Rock, Texas, 78681, United States
Texas Oncology - South Austin Cancer Center

Austin, Texas, 78745, United States
Texas Oncology Cancer Center Sugar Land

Sugar Land, Texas, 77479, United States
Texas Oncology PA - Bedford

Bedford, Texas, 76022, United States
Texas Oncology-Austin Midtown

Austin, Texas, 78705, United States
Texas Oncology-Denton South

Denton, Texas, 76210, United States
Texas Oncology-Seton Williamson

Round Rock, Texas, 78665, United States
Texas Oncology-Wichita Falls Texoma Cancer Center

Wichita Falls, Texas, 76310, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States
The Klabzuba Cancer Center

Fort Worth, Texas, 76104, United States
The Nebraska Medical Center

Omaha, Nebraska, 68198, United States
The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, 95678, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Touro Infirmary

New Orleans, Louisiana, 70115, United States
Tri-Cities Cancer Center

Kennewick, Washington, 99336, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
Tulane University Health Sciences Center

New Orleans, Louisiana, 70112, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCSF-Mount Zion

San Francisco, California, 94115, United States
UF Cancer Center at Orlando Health

Orlando, Florida, 32806, United States
UHHS-Chagrin Highlands Medical Center

Orange, Ohio, 44122, United States
UHHS-Westlake Medical Center

Westlake, Ohio, 44145, United States
UMDNJ - New Jersey Medical School

Newark, New Jersey, 07103, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University Pointe

West Chester, Ohio, 45069, United States
University Radiation Oncology

Rochester, New York, 14626, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of California at Davis Cancer Center

Sacramento, California, 95817, United States
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of Colorado Cancer Center - Anschutz Cancer Pavilion

Aurora, Colorado, 80045, United States
University of Hawaii

Honolulu, Hawaii, 96813, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Missouri - Ellis Fischel

Columbia, Missouri, 65212, United States
University of New Mexico

Albuquerque, New Mexico, 87106, United States
University of North Carolina

Chapel Hill, North Carolina, 27599, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Southern California/Norris Cancer Center

Los Angeles, California, 90033, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Virginia

Charlottesville, Virginia, 22908, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States
Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States
Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University

Richmond, Virginia, 23298, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne Radiation Oncology

Goldsboro, North Carolina, 27534, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
WellSpan Health-York Hospital

York, Pennsylvania, 17405, United States
Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, 37660, United States
Wenatchee Valley Medical Center

Wenatchee, Washington, 98801, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Western Oncology Research Consortium

Portland, Oregon, 97213, United States
Wheeling Hospital

Wheeling, West Virginia, 26003, United States
Willamette Valley Cancer Center

Eugene, Oregon, 97401, United States
William Backus Hospital

Norwich, Connecticut, 06360, United States
Yale University

New Haven, Connecticut, 06520, United States

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