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Blood tests may reveal why some kids suffer more after tonsil surgery

NCT ID NCT06266429

Knowledge-focused Sponsor: Nationwide Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at blood samples from 84 children aged 4-17 having their tonsils removed to find chemical clues about why Black children often report more pain afterward. Researchers will measure pain scores and compare blood metabolites between racial groups. The goal is to understand the biology behind these differences so future treatments can be more personalized and fair.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify biological markers that explain racial differences in post-surgery pain, leading to better, personalized pain treatments for children.
What could go wrong
This is an early observational study with only 84 participants, so findings may not apply to all children. It looks at chemical markers, not a treatment, so direct benefits are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

84 people

The number who actually took part.

Started

Mar 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children undergoing tonsillectomy ± adenoidectomy at Nationwide Children's Hospital.

Ages

4 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Consenting (or assenting) patients age 4-17yr and American Society of Anesthesiologist's (ASA) physical status I-III who are scheduled for elective tonsillectomy ± adenoidectomy (T\&A). Exclusion Criteria: * Age \> 18 years old * Children below 4 years of age because they are routinely admitted following T\&A in our institution and may not be able to clearly self-report their pain * Children on chronic preoperative analgesic medications * Children with Cushing's syndrome, or nephrotic syndrome * Children on chronic systemic steroids * Children with concurrent surgical procedures that could prolong the duration of anesthesia and surgery * Children that do not speak English or cannot self-report their pain after surgery (significant cognitive impairment, anticipated or unplanned postoperative endotracheal intubation, and sedation)

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Conditions

The condition(s) this trial relates to.

adenoid hypertrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adenoid hypertrophy Surgery Tonsillar hypertrophy

Contacts and locations

Locations

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.