New bioactive fillings could make cavity repairs last longer
NCT ID NCT07552350
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares three types of bioactive dental fillings for cavities in back teeth. Fifty-five healthy adults aged 18 to 50 with at least three cavities will receive each filling type in different teeth. Researchers will check how well the fillings hold up, their appearance, and any sensitivity over two years.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dental restorative materials (giomer, giomer-based bulk-fill, resin-modified glass ionomer cement)
- What this could lead to
- If successful, this could identify which bioactive filling material works best for treating cavities in back teeth, potentially improving dental restoration longevity.
- What could go wrong
- This is a small, early-stage trial with only 55 participants, so results may not apply to everyone. The materials might still fail or cause sensitivity over time.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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55 people
The number who actually took part.
- Started
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Feb 2025
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Healthy individuals without any systemic disease that could contraindicate restorative treatment 2. Individuals aged between 18 and 50 years 3. Individuals who agreed to participate in the study and signed the informed consent form 4. Individuals with at least three proximal carious lesions in premolar or molar teeth, classified as D2 (lesions extending to the middle third of dentin) or D3 (lesions extending to the inner third of dentin) according to the ICDAS classification 5. Teeth with intact enamel and dentin structure that had not been previously restored 6. Individuals who brushed their teeth at least twice a day 7. Individuals without physical disabilities that could prevent attendance at follow-up visits 8. Individuals with at least 20 teeth in occlusion and with antagonist teeth in the opposing arch 9. Vital teeth without signs of periapical pathology 10. Periodontally healthy teeth that were not used as abutments for any prosthetic restoration 11. Teeth without displacement or mobility 12. Individuals who had undergone initial periodontal therapy Exclusion Criteria: 1. Pregnant or breastfeeding individuals 2. Individuals with advanced periodontal disease 3. Individuals using removable partial dentures 4. Individuals with bruxism 5. Individuals with severe malocclusion 6. Individuals with known allergies to resin-based restorative materials or adhesive agents 7. Individuals with a history of allergy to local anesthetics or their administration 8. Individuals with latex allergy 9. Individuals with poor oral hygiene 10. Teeth that had been previously restored or were undergoing orthodontic treatment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hacettepe University Faculty of Dentistry, Department of Restorative Dentistry
Ankara, 06230, Turkey (Türkiye)
More trials for these conditions
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