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Which root canal sealer causes less pain? new study investigates

NCT ID NCT07434141

Symptom relief Sponsor: Tehran University of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at pain after root canal treatment in adults with a tooth condition called irreversible pulpitis. Researchers are testing three different sealers (materials used to fill the root canal) to see which one leads to the least pain and need for painkillers. 75 participants will report their pain levels and painkiller use for 48 hours after treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

75 people

The number who actually took part.

Started

Jun 2025

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 60 years * Adequate oral and dental hygiene * Prolonged positive response to cold test and electric pulp testing * Clinical diagnosis of symptomatic irreversible pulpitis and symptomatic apical periodontitis in a first or second molar (maxillary or mandibular) * Pulp exposure during caries removal accompanied by severe and profuse hemorrhage * No radiographic evidence of periapical lesions * Teeth with adequate restorative potential * Absence of periodontal disease Exclusion Criteria: * Teeth that are non-restorable * Presence of endodontic-periodontal (endo-perio) lesions * Teeth with radiographic evidence of periapical lesions * Teeth with internal or external root resorption * Patients with systemic diseases classified as ASA II or higher * Patients with a history of migraine * Teeth with over-obturation or under-obturation greater than 2 mm from the radiographic apex * Patients taking anti-anxiety medications * Procedural duration exceeding two hours * Known allergy to materials used in root canal treatment, including local anesthetics

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Symptomatic irreversible pulpitis (SIP) Symptomatic irreversible pulpitis with apical peridontitis

Contacts and locations

Locations

  • Tehran University of Medical Sciences, School of Dentistry

    Tehran, 1439955991, Iran

More trials for these conditions

Other studies related to the condition(s) this trial covers.