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Can a digestive enzyme combo beat standard painkillers for root canal pain?

NCT ID NCT07759349

Symptom relief Sponsor: Dow University of Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 20, 2026 · Updated 3 times

Summary

This trial tests three pain-relief approaches after a single-visit root canal in people with symptomatic irreversible pulpitis, a painful tooth condition. Participants receive either acetaminophen, an NSAID, or a combination of trypsin-chymotrypsin with acetaminophen for three days. Pain levels are measured before treatment and at several points over 72 hours using a standard pain scale. The goal is to see which option provides the best relief after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acetaminophen, NSAIDs (ibuprofen), and a combination of trypsin-chymotrypsin with acetaminophen
What this could lead to
If successful, this could identify the most effective painkiller for post-root-canal discomfort, helping dentists choose better pain management strategies.
What could go wrong
This is a small early-phase trial, so results may not apply to all patients. Pain relief can vary widely, and the study doesn't guarantee long-term benefits or account for all individual differences.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA * Both sex * Healthy ( American Society of Anesthesiologists class 1) * Age 18-60 years * Pulpal diagnosis: Symptomatic irreversible pulpitis in mandibular premolar (single canal) periapical diagnosis: symptomatic apical periodontitis * The ability of participants to understand a pain scale (VAS) Exclusion Criteria: * Pregnant females * Systemic disease and immune deficiency * Taken analgesics 24 hours, prior to treatment * Non-vital, previously initiated, previously treated teeth * Radiographic evidence of peri-radicular pathosis * Teeth with cracks, fractures and history of trauma * Developmental anomalies and immature apices * Allergic to local anesthetic solution or any experimental drugs * Patient being unable to provide informed consent.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Symptomatic irreversible pulpitis (SIP)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dow University of Health Sciences

    RECRUITING

    Karachi, Sindh, 75600, Pakistan

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