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Chill or zap? new study tests cold and laser to cut root canal pain

NCT ID NCT07627867

Symptom relief Sponsor: Future University in Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using cold or laser-activated fluids during a root canal can reduce pain and kill more bacteria than standard treatment. Sixty adults with an infected lower molar will receive one of four rinses: room-temperature, cold, heated, or laser-activated sodium hypochlorite. Pain levels and bacterial counts will be measured over the next few days to see which approach works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sodium hypochlorite (NaOCl) at different temperatures or activated by laser
What this could lead to
If successful, this could point toward a better way to reduce pain and bacteria after a root canal, making the procedure more comfortable.
What could go wrong
This is a small, early-stage trial with only 60 participants, so results may not apply to everyone. The treatments are compared to standard care, and any benefit may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 to 40 years. * Patients able to understand and sign the informed consent form. * Patients who positively accept to participate in the study. * Patients diagnosed with symptomatic irreversible pulpitis in a restorable mandibular first molar. * The affected tooth must have a mesial and distal root canal configuration classified as Type III according to Vertucci's classification. * The root curvature of the involved canals must be mild to moderate (5-20°), as measured by Schneider's method. * No sex predilection. Exclusion Criteria: * Patients who are pregnant or lactating. * Medically compromised patients (e.g., with systemic conditions that contraindicate dental treatment or affect pain perception). * Patients who have taken any analgesic medication within 8 hours prior to the appointed treatment. * Patients who have taken antibiotics within the two weeks prior to the preoperative assessment. * Patients with parafunctional habits such as bruxism or clenching. * Patients with severe malocclusion associated with traumatic occlusion. * Teeth exhibiting any of the following: * Pain on percussion. * A diagnosis of peri-apical periodontitis or a peri-radicular lesion. * Internal or external root resorption. * Pulp stones or significant canal calcifications. * Evidence of previous endodontic treatment. * Teeth with non-patent canals or canals that cannot be negotiated.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Symptomatic irreversible pulpitis (SIP)

Contacts and locations

Locations

  • Future University in Egypt

    Cairo, New Cairo, 11835, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.