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Tooth pain relief: steroid injection may beat placebo after root canal

NCT ID NCT07233564

Symptom relief Sponsor: College of Physicians and Surgeons Pakistan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single injection of dexamethasone (a steroid) near the tooth can reduce pain after root canal treatment for people with severe, irreversible tooth inflammation. 44 adults with this condition will receive either the steroid or a placebo (salt water) injection. Pain levels are checked at 6, 24, and 48 hours after the procedure. The goal is to see if this simple injection provides better pain relief than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

44 people

The number who actually took part.

Started

Jul 2025

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients age 18 or above 18 year old (to have complete apex formation) * Patient with normal periapical area (no pain on percussion). * Patient who have not received any preoperative analgesic and antibiotic in last one month. Exclusion Criteria: * Pregnancy and Lactation because radiographs are contraindicated. * Moderate to severe periodontal disease because teeth are not salvageable. * Patient with nonvital teeth diagnose via cold test and EPT. * Patient with known sensitivity to dexamethasone by history. * Patients whose medical history include a history of certain illnesses, such as HIV, heart disease, or epilepsy (conditions that can affect a patient's rate of healing).

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irreversible pulpitis

Contacts and locations

Locations

  • Saidu College of Dentistry

    Swāt, Khyber Pakhtunkhwa, 19200, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.