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Your DNA could decide if Tooth-Saving therapy works

NCT ID NCT07130214

Knowledge-focused Sponsor: Ataturk University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a person's genetic makeup influences how well a dental treatment called vital pulp therapy works for saving teeth with pulpitis (tooth nerve inflammation). Researchers will collect saliva from 96 participants to analyze specific genes, then track treatment success over 12 months using exams and X-rays. The goal is to understand why some people respond better to this tooth-preserving procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

96 people

The number who actually took part.

Started

May 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Ataturk University Faculty of Dentistry Endodontics Department

Ages

16 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * permanent teeth diagnosed with reversible pulpitis, * patients diagnosed with irreversible pulpitis but without apical radiolucency, -teeth responding within normal limits to cold stimuli (using carbon dioxide snow), * teeth with prolonged response to cold testing, diagnosed with irreversible pulpitis, * teeth without sensitivity to percussion or chewing tests, * teeth with bleeding time less than 5 minutes from exposed pulp tissue, * teeth diagnosed with irreversible pulpitis with bleeding time less than 10 minutes, * teeth without widening of the periodontal ligament space (Periapical Index \[PAI\] ≥2), * teeth with radiographically confirmed deep dentinal caries, * patients classified as ASA I (American Society of Anesthesiologists Physical Status Classification) Exclusion Criteria: * teeth showing negative response to cold testing (using carbon dioxide snow), -teeth showing negative response to electric pulp testing, * presence of apical radiolucency (PAI \> 2), * presence of condensing apical periodontitis in the relevant tooth, * teeth with internal or external root resorption, * teeth with a history of trauma, * teeth with vertical root fractures, * evidence of periodontal-endodontic lesion on the day of treatment, * loss of function (e.g., tooth mobility degree 3), * presence of swelling related to the treated tooth, * teeth that cannot be treated with rubber dam isolation, * patients with compromised immune systems, * patients who are pregnant at the time of treatment, * patients who have used antibiotics, bisphosphonates, or statins within the last 4 weeks prior to treatment.

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Conditions

The condition(s) this trial relates to.

dental pulp disorder exposure, dental pulp pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulp caping Pulp disease, dental Pulp exposure, dental Pulpal inflammation Pulpitis Pulpitis - irreversible

Contacts and locations

Locations

  • Ataturk University

    Erzurum, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.