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Gel boosts gum healing after deep cleaning for advanced periodontitis — trial puts it to the test

NCT ID NCT07731113

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This trial tests whether applying a gel containing hyaluronic acid and chlorhexidine after a minimally invasive deep cleaning can improve gum healing in people with advanced periodontitis (stage III or IV). Participants receive either the deep cleaning alone or the cleaning plus the gel. The study measures changes in pocket depth and gum attachment levels to see if the gel provides extra benefit.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a gel containing hyaluronic acid and chlorhexidine (Periofix Plus Gel)
What this could lead to
If it works, this could offer a simple, in-office way to improve gum healing and reduce pocket depth in advanced periodontitis without surgery.
What could go wrong
This is a small, early-stage trial. The gel may not provide significant added benefit over standard care, and individual results may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

72 people

The number who actually took part.

Started

Mar 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 25-70 * Diagnosis of 'periodontitis' stage III or IV (grades A to C) * Presence of ≥ 1 'intrabony defect' (PPD, \> 5 mm with intrabony defect depth ≥ 3 mm at screening radiograph) * Signed informed consent Exclusion Criteria: * Smoking (current or in past 5 years) * Medical history including diabetes or hepatic or renal disease or other serious medical conditions or transmittable diseases * History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures * Anti-inflammatory or anticoagulant therapy during the month preceding the baseline exam * Systemic antibiotic therapy during the 3 months preceding the baseline exam * History of alcohol or drug abuse * Self-reported pregnancy or lactation * Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that according to the investigator may increase the risk associated with trial participation * Periodontal treatment to the study site within the last 12 months

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Conditions

The condition(s) this trial relates to.

gingivitis periodontal disorder Periodontal Pocket periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adjunctive periodontal therapy Biofilm control Clinical attachment level Gingivitis and periodontal diseases Hyaluronic acid Hyaluronic acid and chlorhexidine gel Minimally invasive non-surgical therapy (minst) Non-surgical periodontal therapy Periodontal disease Periodontal diseases Periodontitis (stage 3) Periodontology Periofix plus gel Probing pocket depth Stage III periodontitis Stage IV periodontitis

Contacts and locations

Locations

  • Faculty of Oral and Dental Medicine. Cairo University

    Giza, Giza Governorate, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.