Amniotic membrane could help Kids' teeth grow back stronger
NCT ID NCT07336498
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests three materials—amniotic membrane, mineral trioxide aggregate putty, and biodentine—for treating deep cavities in children's permanent molars that are still growing. The goal is to help the tooth root finish developing and avoid root canal or extraction. Seventy-five healthy children aged 7 to 10 will receive one of the treatments, and their teeth will be checked for pain, swelling, and root growth using 3D X-rays over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- amniotic membrane, putty mineral trioxide aggregate, and biodentine
- What this could lead to
- If successful, this could provide a better way to treat damaged immature teeth in children, helping them grow normally and avoid extraction.
- What could go wrong
- This is a small, early-stage trial with only 75 participants. Results may not apply to all children, and the treatments may not work as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 75 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2025
- Expected to finish
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Apr 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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7 to 10 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy patients without any systemic disease aged 7 to 10 years old. * Vital immature permanent molars with deep carious lesions. * Restorable tooth * No clinical signs and symptoms of irreversible pulpitis including spontaneous pain, tenderness to percussion, swelling or sinus tract. * No radiographic evidence of periapical abscess, internal or external resorption. Exclusion Criteria: * Patients with known allergies to any of the dental materials to be used. * Bleeding could not be controlled within 5 minutes after complete pulpotomy * Teeth with root fractures * Carious furcation involvement
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of Dentistry, Al-Azhar University, Cairo (Boys Branch)
Cairo, Egypt