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Smoking's hidden toll on gum health revealed

NCT ID NCT07563192

Knowledge-focused Sponsor: Suleyman Demirel University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at how smoking changes the body's immune response in gum disease. Researchers compared smokers and non-smokers with healthy gums, gingivitis, or periodontitis. They measured specific proteins and genes in gum tissue to understand the link between smoking and inflammation. The goal is to learn more about why smokers often have worse gum disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

113 people

The number who actually took part.

Started

Oct 2024

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of individuals who applied to the Department of Periodontology at the Faculty of Dentistry. Participants include systemically healthy volunteers diagnosed with different periodontal conditions (healthy, gingivitis, or periodontitis) and categorized by their smoking status.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals who voluntarily agreed to participate in the study, * Smokers (gingivitis and stage 3/4 generalized periodontitis) and non-smokers (gingivitis and stage 3/4 generalized periodontitis) who applied to the Periodontology Clinical of Suleyman Demirel University Faculty of Dentistry, * Individuals without any systemic diseases and without using any medications that affect periodontal health were included. Exclusion Criteria: * Individuals who refuse to participate in the study or who cannot comply with the study protocol, * Individuals participating in another clinical trial concurrently, Individuals who have received periodontal treatment within the last 6 months, * Individuals who have used medications (antibiotics, anti-inflammatory drugs, etc.) that may affect periodontal parameters within the last 3 months, * Individuals with systemic diseases that may affect the periodontium, * Individuals with systemic diseases presenting with oral symptoms, * Individuals with malignant disease, * Pregnant or lactating women, * Individuals with psychological or physical disabilities, * Individuals with substance abuse, * Individuals with severe malocclusion, undergoing orthodontic treatment, using appliances, or using removable dentures, * Individuals with acute dental infection or pain (cavities, abscesses, etc.).

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking gingivitis periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis Periodontal diseases Periodontitis Smoking, cigarette

Contacts and locations

Locations

  • Suleyman Demirel University, Faculty of Dentistry, Department of Periodontology

    Isparta, Isparta, 32000, Turkey (Türkiye)

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